OMIA 001617-9694 : Sweet taste, lack of in Panthera tigris |
In other species:
domestic cat
,
cheetah
Mendelian trait/disorder:
yes
Considered a defect:
yes
Key variant known:
yes
Year key variant first reported:
2005
Cross-species summary:
By sequencing very likely candidate genes (i.e. "genes involved in the initial transduction of sweet perception [which] might account for the indifference to sweet-tasting foods by cats"), Li et al. (2005) provided convincing evidence that one of the two genes required for the heteromer T1R2/T1R3 sweet-taste receptor, namely TAS1R2, is a non-functional pseudogene in all cats, tigers and cheetahs: in these species, the TAS1R2 gene has "a 247-base pair microdeletion in exon 3 and stop codons in exons 4 and 6" (Li et al., 2005). The authors argued that it seems likely that this same pseudogene may exist in all felidae.
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| TAS1R2 | Panthera tigris | - | no genomic information (-..-) | TAS1R2 | Ensembl |
Variants
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| Breed(s) | Variant Phenotype | Gene | Allele | Type of Variant | Reference Sequence | Chr. | g. or m. | c. or n. | p. | Verbal Description | EVA ID | Year Published | PubMed ID(s) | Acknowledgements |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sweet taste, lack | TAS1R2 | deletion, gross (>20) | "a 247-base pair microdeletion in exon 3 and stop codons in exons 4 and 6" | 2005 | 16103917 |
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2006 | Li, X., Li, W., Wang, H., Bayley, D.L., Cao, J., Reed, D.R., Bachmanov, A.A., Huang, L., Legrand-Defretin, V., Beauchamp, G.K., Brand, J.G. : | |
| Cats lack a sweet taste receptor. J Nutr 136:1932S-1934S, 2006. Pubmed reference: 16772462. | ||
| 2005 | Li, X., Li, W., Wang, H., Cao, J., Maehashi, K., Huang, L., Bachmanov, A.A., Reed, D.R., Legrand-Defretin, V., Beauchamp, G.K., Brand, J.G. : | |
| Pseudogenization of a sweet-receptor gene accounts for cats' indifference toward sugar. PLoS Genet 1:27-35, 2005. Pubmed reference: 16103917. DOI: 10.1371/journal.pgen.0010003. |
Edit History
- Created by Frank Nicholas on 04 Oct 2011
- Changed by Frank Nicholas on 22 Mar 2012