OMIA:001744-9925 : Mastitis, susceptibility/resistance to in Capra hircus (goat) |
In other species: taurine cattle , indicine cattle (zebu) , sheep , rabbit , water buffalo
Categories: Immune system phene
Single-gene trait/disorder: no
Mode of inheritance: Multifactorial
Disease-related: no
Key variant known: no
Molecular basis: Feng et al. (2024) created gene-edited dairy goats (GED) via 'targeted integration of an innate inflammatory regulatory sequence (IRS) into the promoter region of the lysozyme (LYZ) gene. Upon Escherichia Coli (E. coli) mammary gland infection, GED goats exhibited increased LYZ expression, showing robust anti-mastitis capabilities, mitigating PANoptosis activation, and alleviating blood-milk-barrier (BMB) damage.' This study involves genetically modified organisms (GMO).
Genetic engineering:
Yes - in addition to the occurrence of natural variants, variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2024). OMIA:001744-9925: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2024 | Aguirre-Arroyo, E., Castañeda-Bustos, V.J., Lechuga-Arana, A.A., Gutiérrez-Chávez, A.J., Ángel-Sahagún, C.A., Hernández-Marín, J.A., Valencia-Posadas, M. : |
| Genetic parameters for reproductive traits and somatic cell score in U.S. dairy goats. Trop Anim Health Prod 56:170, 2024. Pubmed reference: 38769239. DOI: 10.1007/s11250-024-04001-2. | |
| Ebissy, E., Darwish, A., Hafez, A.A., Ateya, A., El-Sayed, A. : | |
| Individual genomic loci, transcript level, and biochemical profile of immune and antioxidant markers associated with genetically identified bacterial mastitis in Shami goats in Egypt. Open Vet J 14:370-388, 2024. Pubmed reference: 38633191. DOI: 10.5455/OVJ.2024.v14.i1.34. | |
| Feng, R., Zhao, J., Zhang, Q., Zhu, Z., Zhang, J., Liu, C., Zheng, X., Wang, F., Su, J., Ma, X., Mi, X., Guo, L., Yan, X., Liu, Y., Li, H., Chen, X., Deng, Y., Wang, G., Zhang, Y., Liu, X., Liu, J. : | |
| Generation of anti-mastitis gene-edited dairy goats with enhancing lysozyme expression by inflammatory regulatory sequence using ISDra2-TnpB system. Adv Sci (Weinh) 11:2404408:e2404408, 2024. Pubmed reference: 39099401. DOI: 10.1002/advs.202404408. | |
| Gudra, D., Valdovska, A., Jonkus, D., Kairisa, D., Galina, D., Ustinova, M., Viksne, K., Fridmanis, D., Kalnina, I. : | |
| Genetic characterization of the Latvian local goat breed and genetic traits associated with somatic cell count. Animal 18:S1751-7311(24)00085-5:101154, 2024. Pubmed reference: 38703755. DOI: 10.1016/j.animal.2024.101154. | |
| 2019 | Rupp, R., Huau, C., Caillat, H., Fassier, T., Bouvier, F., Pampouille, E., Clément, V., Palhière, I., Larroque, H., Tosser-Klopp, G., Jacquiet, P., Rainard, P. : |
| Divergent selection on milk somatic cell count in goats improves udder health and milk quality with no effect on nematode resistance. J Dairy Sci 102:5242-5253, 2019. Pubmed reference: 30904305. DOI: 10.3168/jds.2018-15664. | |
| 2018 | Ilie, D.E., Kusza, S., Sauer, M., Gavojdian, D. : |
| Genetic characterization of indigenous goat breeds in Romania and Hungary with a special focus on genetic resistance to mastitis and gastrointestinal parasitism based on 40 SNPs. PLoS One 13:e0197051, 2018. Pubmed reference: 29742137. DOI: 10.1371/journal.pone.0197051. | |
| Martin, P., Palhière, I., Maroteau, C., Clément, V., David, I., Klopp, G.T., Rupp, R. : | |
| Genome-wide association mapping for type and mammary health traits in French dairy goats identifies a pleiotropic region on chromosome 19 in the Saanen breed. J Dairy Sci 101:5214-5226, 2018. Pubmed reference: 29573797. DOI: 10.3168/jds.2017-13625. | |
| 2015 | Bishop, S.C. : |
| Genetic resistance to infections in sheep. Vet Microbiol 181:2-7, 2015. Pubmed reference: 26260859. DOI: 10.1016/j.vetmic.2015.07.013. | |
| 2013 | Liu, J., Luo, Y., Ge, H., Han, C., Zhang, H., Wang, Y., Su, J., Quan, F., Gao, M., Zhang, Y. : |
| Anti-bacterial activity of recombinant human β-defensin-3 secreted in the milk of transgenic goats produced by somatic cell nuclear transfer. PLoS One 8:e65379, 2013. Pubmed reference: 23799010. DOI: 10.1371/journal.pone.0065379. | |
| 2003 | Bergonier, D., de Crémoux, R., Rupp, R., Lagriffoul, G., Berthelot, X. : |
| Mastitis of dairy small ruminants. Vet Res 34:689-716, 2003. Pubmed reference: 14556701. DOI: 10.1051/vetres:2003030. |
Edit History
- Created by Frank Nicholas on 01 Apr 2020
- Changed by Imke Tammen2 on 06 Aug 2024