OMIA 001744-9913 : Resistance to mastitis in Bos taurus

In other species: goat , sheep

Mendelian trait/disorder: no

Mode of inheritance: Multifactorial

Considered a defect: no

Key variant known: no

Species-specific description: Resistance to mastitis is a classic quantitative/multifactorial/complex trait. Typically it is quantified in terms of a somatic cell count (SCC) from a sample of milk. The trait is sufficiently heritable to have been included in many herd improvement programs around the world. In recent years, genome-wide association studies (GWAS) with SNP chips have begun to identify QTL for this trait. As yet there are no agreed quantitative trait nucleotides (QTN).


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2020 Freebern, E., Santos, D.J.A., Fang, L., Jiang, J., Parker Gaddis, K.L., Liu, G.E., VanRaden, P.M., Maltecca, C., Cole, J.B., Ma, L. :
GWAS and fine-mapping of livability and six disease traits in Holstein cattle. BMC Genomics 21:41, 2020. Pubmed reference: 31931710. DOI: 10.1186/s12864-020-6461-z.
Lopes, F., Rosa, G., Pinedo, P., Santos, J.E.P., Chebel, R.C., Galvao, K.N., Schuenemann, G.M., Bicalho, R.C., Gilbert, R.O., Rodrigez-Zas, S., Seabury, C.M., Thatcher, W. :
Genome-enable prediction for health traits using high-density SNP panel in US Holstein cattle. Anim Genet :, 2020. Pubmed reference: 31909828. DOI: 10.1111/age.12892.
2019 Khan, M.Z., Wang, D., Liu, L., Usman, T., Wen, H., Zhang, R., Liu, S., Shi, L., Mi, S., Xiao, W., Yu, Y. :
Significant genetic effects of <i>JAK2</i> and <i>DGAT1</i> mutations on milk fat content and mastitis resistance in Holsteins. J Dairy Res :1-6, 2019. Pubmed reference: 31779717. DOI: 10.1017/S0022029919000682.
Li, L., Chen, X., Chen, Z. :
Identification of Key Candidate Genes in Dairy Cow in Response to <i>Escherichia coli</i> Mastitis by Bioinformatical Analysis. Front Genet 10:1251, 2019. Pubmed reference: 31921295. DOI: 10.3389/fgene.2019.01251.
Szyda, J., Mielczarek, M., Frąszczak, M., Minozzi, G., Williams, J.L., Wojdak-Maksymiec, K., Szyda, J., Mielczarek, M., Frąszczak, M., Minozzi, G., Williams, J.L., Wojdak-Maksymiec, K., Szyda, J., Mielczarek, M., Frąszczak, M., Minozzi, G., Williams, J.L., Wojdak-Maksymiec, K. :
The genetic background of clinical mastitis in Holstein-Friesian cattle. Animal 13:2156-2163, 2019. Pubmed reference: 30835192. DOI: 10.1017/S1751731119000338.
Weller, J.I., Ezra, E., van Straten, M. :
Genetic and environmental analysis of diseases with major economic impact in Israeli Holsteins. J Dairy Sci 102:10030-10038, 2019. Pubmed reference: 31521347. DOI: 10.3168/jds.2018-16026.
2018 Martin, P., Barkema, H.W., Brito, L.F., Narayana, S.G., Miglior, F. :
Symposium review: Novel strategies to genetically improve mastitis resistance in dairy cattle. J Dairy Sci :, 2018. Pubmed reference: 29331471. DOI: 10.3168/jds.2017-13554.
Naderi, S., Bohlouli, M., Yin, T., König, S. :
Genomic breeding values, SNP effects and gene identification for disease traits in cow training sets. Anim Genet :, 2018. Pubmed reference: 29624705. DOI: 10.1111/age.12661.
Weigel, K.A., Shook, G.E. :
Genetic Selection for Mastitis Resistance Veterinary Clinics of North America: Food Animal Practice 34:457-472 , 2018. DOI: 10.1016/j.cvfa.2018.07.001.
2017 Mahmoud, M., Yin, T., Brügemann, K., König, S. :
Phenotypic, genetic, and single nucleotide polymorphism marker associations between calf diseases and subsequent performance and disease occurrences of first-lactation German Holstein cows. J Dairy Sci 100:2017-2031, 2017. Pubmed reference: 28109590. DOI: 10.3168/jds.2016-11767.
Ruegg, P.L. :
A 100-Year Review: Mastitis detection, management, and prevention. J Dairy Sci 100:10381-10397, 2017. Pubmed reference: 29153171. DOI: 10.3168/jds.2017-13023.
2016 Tsiamadis, V., Banos, G., Panousis, N., Kritsepi-Konstantinou, M., Arsenos, G., Valergakis, G.E. :
Genetic parameters of subclinical macromineral disorders and major clinical diseases in postparturient Holstein cows. J Dairy Sci 99:8901-8914, 2016. Pubmed reference: 27614830. DOI: 10.3168/jds.2015-10789.
2015 Kadri, N.K., Guldbrandtsen, B., Lund, M.S., Sahana, G. :
Genetic dissection of milk yield traits and mastitis resistance quantitative trait loci on chromosome 20 in dairy cattle. J Dairy Sci 98:9015-25, 2015. Pubmed reference: 26409972. DOI: 10.3168/jds.2015-9599.
2014 Bludau, M.J., Maeschli, A., Leiber, F., Steiner, A., Klocke, P. :
Mastitis in dairy heifers: prevalence and risk factors. Vet J 202:566-72, 2014. Pubmed reference: 25457268. DOI: 10.1016/j.tvjl.2014.09.021.
Wang, X., Zhong, J., Gao, Y., Ju, Z., Huang, J. :
A SNP in intron 8 of CD46 causes a novel transcript associated with mastitis in Holsteins. BMC Genomics 15:630, 2014. Pubmed reference: 25070150. DOI: 10.1186/1471-2164-15-630.
2013 Deb, R., Kumar, A., Chakraborty, S., Verma, A.K., Tiwari, R., Dhama, K., Singh, U., Kumar, S. :
Trends in diagnosis and control of bovine mastitis: a review. Pak J Biol Sci 16:1653-61, 2013. Pubmed reference: 24506032.
Haugaard, K., Heringstad, B., Whist, A.C. :
Genetic associations between somatic cell score and pathogen-specific subclinical mastitis in Norwegian Red cows. J Anim Breed Genet 130:98-105, 2013. Pubmed reference: 23496010. DOI: 10.1111/jbg.12019.
Sahana, G., Guldbrandtsen, B., Thomsen, B., Lund, M.S. :
Confirmation and fine-mapping of clinical mastitis and somatic cell score QTL in Nordic Holstein cattle. Anim Genet :, 2013. Pubmed reference: 23647142. DOI: 10.1111/age.12053.
2012 Holmberg, M., Fikse, W.F., Andersson-Eklund, L., Artursson, K., Lundén, A. :
Genetic analyses of pathogen-specific mastitis. J Anim Breed Genet 129:129-37, 2012. Pubmed reference: 22394235. DOI: 10.1111/j.1439-0388.2011.00945.x.
Koeck, A., Miglior, F., Kelton, D.F., Schenkel, F.S. :
Short communication: Genetic parameters for mastitis and its predictors in Canadian Holsteins. J Dairy Sci 95:7363-6, 2012. Pubmed reference: 23021760. DOI: 10.3168/jds.2012-5648.
Meredith, B.K., Kearney, F.J., Finlay, E.K., Bradley, D.G., Fahey, A.G., Berry, D.P., Lynn, D.J. :
Genome-wide associations for milk production and somatic cell score in Holstein-Friesian cattle in Ireland. BMC Genet 13:21, 2012. Pubmed reference: 22449276. DOI: 10.1186/1471-2156-13-21.
Pighetti, G.M., Kojima, C.J., Wojakiewicz, L., Rambeaud, M. :
The bovine CXCR1 gene is highly polymorphic. Vet Immunol Immunopathol 145:464-70, 2012. Pubmed reference: 22056270. DOI: 10.1016/j.vetimm.2011.09.012.
Sørensen, L.P., Janss, L., Madsen, P., Mark, T., Lund, M.S. :
Estimation of (co)variances for genomic regions of flexible sizes: application to complex infectious udder diseases in dairy cattle. Genet Sel Evol 44:18, 2012. Pubmed reference: 22640006. DOI: 10.1186/1297-9686-44-18.
Wijga, S., Bastiaansen, J.W., Wall, E., Strandberg, E., de Haas, Y., Giblin, L., Bovenhuis, H. :
Genomic associations with somatic cell score in first-lactation Holstein cows. J Dairy Sci 95:899-908, 2012. Pubmed reference: 22281354. DOI: 10.3168/jds.2011-4717.
Yuan, Z., Chu, G., Dan, Y., Li, J., Zhang, L., Gao, X., Gao, H., Li, J., Xu, S., Liu, Z. :
BRCA1: a new candidate gene for bovine mastitis and its association analysis between single nucleotide polymorphisms and milk somatic cell score. Mol Biol Rep 39:6625-31, 2012. Pubmed reference: 22327776. DOI: 10.1007/s11033-012-1467-5.
2011 Martins, A.M., Silvestre, A.M., Petim-Batista, M.F., Colaço, J.A. :
Somatic cell score genetic parameter estimates of dairy cattle in Portugal using fractional polynomials. J Anim Sci 89:1281-5, 2011. Pubmed reference: 21521811. DOI: 10.2527/jas.2010-3211.
Mulder, H.A., Lidauer, M.H., Vilkki, J.H., Strandén, I., Veerkamp, R.F. :
Marker-assisted breeding value estimation for mastitis resistance in Finnish Ayrshire cattle. J Dairy Sci 94:4164-73, 2011. Pubmed reference: 21787951. DOI: 10.3168/jds.2010-4112.
2010 Tal-Stein, R., Fontanesi, L., Dolezal, M., Scotti, E., Bagnato, A., Russo, V., Canavesi, F., Friedmann, A., Soller, M., Lipkin, E. :
A genome scan for quantitative trait loci affecting milk somatic cell score in Israeli and Italian Holstein cows by means of selective DNA pooling with single- and multiple-marker mapping. J Dairy Sci 93:4913-27, 2010. Pubmed reference: 20855026. DOI: 10.3168/jds.2010-3254.
Windig, J.J., Ouweltjes, W., Ten Napel, J., de Jong, G., Veerkamp, R.F., De Haas, Y. :
Combining somatic cell count traits for optimal selection against mastitis. J Dairy Sci 93:1690-701, 2010. Pubmed reference: 20338447. DOI: 10.3168/jds.2009-2052.
2009 Detilleux, J.C. :
Genetic factors affecting susceptibility to udder pathogens. Vet Microbiol 134:157-64, 2009. Pubmed reference: 18930606. DOI: 10.1016/j.vetmic.2008.09.023.
Nilsen, H., Olsen, H.G., Hayes, B., Nome, T., Sehested, E., Svendsen, M., Meuwissen, T.H., Lien, S. :
Characterization of a QTL region affecting clinical mastitis and protein yield on BTA6. Anim Genet 40:701-12, 2009. Pubmed reference: 19466933. DOI: 10.1111/j.1365-2052.2009.01908.x.
Schulman, N.F., Sahana, G., Iso-Touru, T., Lund, M.S., Andersson-Eklund, L., Viitala, S.M., Värv, S., Viinalass, H., Vilkki, J.H. :
Fine mapping of quantitative trait loci for mastitis resistance on bovine chromosome 11. Anim Genet 40:509-15, 2009. Pubmed reference: 19397517. DOI: 10.1111/j.1365-2052.2009.01872.x.
Sørensen, L.P., Madsen, P., Mark, T., Lund, M.S. :
Genetic parameters for pathogen-specific mastitis resistance in Danish Holstein Cattle. Animal 3:647-56, 2009. Pubmed reference: 22444442. DOI: 10.1017/S1751731109003899.
2008 Sahana, G., Lund, M.S., Andersson-Eklund, L., Hastings, N., Fernandez, A., Iso-Touru, T., Thomsen, B., Viitala, S., Sørensen, P., Williams, J.L., Vilkki, J. :
Fine-mapping QTL for mastitis resistance on BTA9 in three Nordic red cattle breeds. Anim Genet 39:354-62, 2008. Pubmed reference: 18462482. DOI: 10.1111/j.1365-2052.2008.01729.x.
2007 Heringstad, B., Klemetsdal, G., Steine, T. :
Selection responses for disease resistance in two selection experiments with Norwegian red cows. J Dairy Sci 90:2419-26, 2007. Pubmed reference: 17430946. DOI: 10.3168/jds.2006-805.
Morris, C.A. :
A review of genetic resistance to disease in Bos taurus cattle. Vet J 174:481-91, 2007. Pubmed reference: 17095270. DOI: 10.1016/j.tvjl.2006.09.006.
2006 Zwald, N.R., Weigel, K.A., Chang, Y.M., Welper, R.D., Clay, J.S. :
Genetic analysis of clinical mastitis data from on-farm management software using threshold models. J Dairy Sci 89:330-6, 2006. Pubmed reference: 16357297. DOI: 10.3168/jds.S0022-0302(06)72098-7.
2005 Heringstad, B., Chang, Y.M., Gianola, D., Klemetsdal, G. :
Genetic analysis of clinical mastitis, milk fever, ketosis, and retained placenta in three lactations of Norwegian red cows. J Dairy Sci 88:3273-81, 2005. Pubmed reference: 16107417. DOI: 10.3168/jds.S0022-0302(05)73010-1.
Koivula, M., Mäntysaari, E.A., Negussie, E., Serenius, T. :
Genetic and phenotypic relationships among milk yield and somatic cell count before and after clinical mastitis. J Dairy Sci 88:827-33, 2005. Pubmed reference: 15653550. DOI: 10.3168/jds.S0022-0302(05)72747-8.
Odegård, J., Klemetsdal, G., Heringstad, B. :
Genetic improvement in mastitis resistance: comparison of selection criteria from cross-sectional and random regression sire models for somatic cell score. J Dairy Sci 88:1515-20, 2005. Pubmed reference: 15778321. DOI: 10.3168/jds.S0022-0302(05)72820-4.
Saebø, S., Almøy, T., Heringstad, B., Klemetsdal, G., Aastveit, A.H. :
Genetic evaluation of mastitis resistance using a first-passage time model for wiener processes for analysis of time to first treatment. J Dairy Sci 88:834-41, 2005. Pubmed reference: 15653551. DOI: 10.3168/jds.S0022-0302(05)72748-X.
2004 Saebø, S., Frigessi, A. :
A genetic and spatial Bayesian analysis of mastitis resistance. Genet Sel Evol 36:527-42, 2004. Pubmed reference: 15339631. DOI: 10.1051/gse:2004015.
2003 Heringstad, B., Klemetsdal, G., Steine, T. :
Selection responses for clinical mastitis and protein yield in two Norwegian dairy cattle selection experiments. J Dairy Sci 86:2990-9, 2003. Pubmed reference: 14507036. DOI: 10.3168/jds.S0022-0302(03)73897-1.
Odegård, J., Klemetsdal, G., Heringstad, B. :
Genetic improvement of mastitis resistance: validation of somatic cell score and clinical mastitis as selection criteria. J Dairy Sci 86:4129-36, 2003. Pubmed reference: 14740854. DOI: 10.3168/jds.S0022-0302(03)74027-2.
Rupp, R., Boichard, D. :
Genetics of resistance to mastitis in dairy cattle. Vet Res 34:671-88, 2003. Pubmed reference: 14556700. DOI: 10.1051/vetres:2003020.
2002 Detilleux, J.C. :
Genetic factors affecting susceptibility of dairy cows to udder pathogens. Vet Immunol Immunopathol 88:103-10, 2002. Pubmed reference: 12127409.
1994 Dekkers, J.C., Mallard, B.A., Leslie, K.E. :
Workshop: genetic improvement of resistance to mastitis of dairy cattle with special emphasis on somatic cell count. J Dairy Sci 77:616-8, 1994. Pubmed reference: 7910175.
Shook, G.E., Schutz, M.M. :
Selection on somatic cell score to improve resistance to mastitis in the United States. J Dairy Sci 77:648-58, 1994. Pubmed reference: 8182190. DOI: 10.3168/jds.S0022-0302(94)76995-2.
1989 Shook, G.E. :
Selection for disease resistance. J Dairy Sci 72:1349-62, 1989. Pubmed reference: 2663944. DOI: 10.3168/jds.S0022-0302(89)79242-0.
1987 Vecht, U., Shook, G.E., Politiek, R.D., Grootenhuis, G. :
[Milk cell count as a selection criterion in breeding dairy cattle with improved resistance to mastitis]. Tijdschr Diergeneeskd 112:598-603, 1987. Pubmed reference: 3590134.
1979 Alrawi, A.A., Laben, R.C., Pollak, E.J. :
Genetic analysis of California mastitis test records. II. Score for resistance to elevated tests. J Dairy Sci 62:1125-31, 1979. Pubmed reference: 512135.
1973 Kushner, K.h.F., Velitok, I.G., Sebryakov, E.V., Sergienko, N.A. :
Phenotypic and genetic parameters of the functional characteristics of the udder quarters in cows. IV. Development of udder quarters and resistance of cows to mastitis. Sov Genet 7:1022-9, 1973. Pubmed reference: 4783217.
1966 Mitscherlind, E., Hogreve, F., Koch, J., Scupin, E. :
[Studies on the correlation between the resistance to mastitis and the bloodgrouping factors in Holstein-Frisian cattle]. Dtsch Tierarztl Wochenschr 73:97-102, 1966. Pubmed reference: 6008685.

Edit History

  • Created by Frank Nicholas on 25 Nov 2012
  • Changed by Frank Nicholas on 25 Nov 2012