OMIA 001744-9913 : Mastitis, susceptibility/resistance to in Bos taurus

In other species: goat , sheep , water buffalo

Mendelian trait/disorder: no

Mode of inheritance: Multifactorial

Considered a defect: no

Key variant known: no

Species-specific description: Resistance to mastitis is a classic quantitative/multifactorial/complex trait. Typically it is quantified in terms of a somatic cell count (SCC) from a sample of milk. The trait is sufficiently heritable to have been included in many herd improvement programs around the world. In recent years, genome-wide association studies (GWAS) with SNP chips have begun to identify QTL for this trait. As yet there are no agreed quantitative trait nucleotides (QTN).

Liu et al. (2014): "report the production of cloned cows carrying human lysozyme gene knock-in β-casein locus using ZFNs." This study involves genetically modified organisms (GMO).

Mapping: Lee et al. (2021) “a prominent CM [clinical mastitis] resistance QTL located on chromosome 6 was reported in various dairy cattle breeds. … Herein, we mapped, fine-mapped, and discovered the putative causal variant underlying this CM resistance QTL in the Dutch dairy cattle population. We identified a ~12 kb multi-allelic copy number variant (CNV), that is in perfect linkage disequilibrium with a lead SNP, as a promising candidate variant. By implementing a fine-mapping and through expression QTL mapping, we showed that the group-specific component gene (GC), a gene encoding a vitamin D binding protein, is an excellent candidate causal gene for the QTL. The multiplicated alleles are associated with increased GC expression and low CM resistance. Ample evidence from functional genomics data supports the presence of an enhancer within this CNV, which would exert cis-regulatory effect on GC.”

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2021 Čítek, J., Brzáková, M., Hanusová, L., Hanuš, O., Večerek, L., Samková, E., Jozová, E., Hoštičková, I., Trávníček, J., Klojda, M., Hasoňová, L. :
Somatic cell score: gene polymorphisms and other effects in Holstein and Simmental cows. Anim Biosci :, 2021. Pubmed reference: 33902174. DOI: 10.5713/ab.20.0720.
Lee, Y.L., Takeda, H., Costa Monteiro Moreira, G., Karim, L., Mullaart, E., Coppieters, W. :
A 12 kb multi-allelic copy number variation encompassing a GC gene enhancer is associated with mastitis resistance in dairy cattle. PLoS Genet 17:e1009331, 2021. Pubmed reference: 34288907. DOI: 10.1371/journal.pgen.1009331.
Miles, A.M., Huson, H.J. :
Graduate Student Literature Review: Understanding the genetic mechanisms underlying mastitis. J Dairy Sci 104:1183-1191, 2021. Pubmed reference: 33162090. DOI: 10.3168/jds.2020-18297.
Singh, P., Ali, S.A. :
Impact of CRISPR-Cas9-based genome engineering in farm animals. Vet Sci 8:, 2021. Pubmed reference: 34209174. DOI: 10.3390/vetsci8070122.
2020 Freebern, E., Santos, D.J.A., Fang, L., Jiang, J., Parker Gaddis, K.L., Liu, G.E., VanRaden, P.M., Maltecca, C., Cole, J.B., Ma, L. :
GWAS and fine-mapping of livability and six disease traits in Holstein cattle. BMC Genomics 21:41, 2020. Pubmed reference: 31931710. DOI: 10.1186/s12864-020-6461-z.
Jeretina, J., Jevšinek Skok, D. :
Genes associated with somatic cell count index in Brown Swiss cattle. J Anim Sci 98:, 2020. Pubmed reference: 33033824. DOI: 10.1093/jas/skaa330.
Kirsanova, E., Heringstad, B., Lewandowska-Sabat, A., Olsaker, I. :
Identification of candidate genes affecting chronic subclinical mastitis in Norwegian Red cattle: combining genome-wide association study, topologically associated domains and pathway enrichment analysis. Anim Genet 51:22-31, 2020. Pubmed reference: 31808564. DOI: 10.1111/age.12886.
Lopes, F., Rosa, G., Pinedo, P., Santos, J.E.P., Chebel, R.C., Galvao, K.N., Schuenemann, G.M., Bicalho, R.C., Gilbert, R.O., Rodrigez-Zas, S., Seabury, C.M., Thatcher, W. :
Genome-enable prediction for health traits using high-density SNP panel in US Holstein cattle. Anim Genet :, 2020. Pubmed reference: 31909828. DOI: 10.1111/age.12892.
2019 Khan, M.Z., Wang, D., Liu, L., Usman, T., Wen, H., Zhang, R., Liu, S., Shi, L., Mi, S., Xiao, W., Yu, Y. :
Significant genetic effects of JAK2 and DGAT1 mutations on milk fat content and mastitis resistance in Holsteins. J Dairy Res :1-6, 2019. Pubmed reference: 31779717. DOI: 10.1017/S0022029919000682.
Li, L., Chen, X., Chen, Z. :
Identification of key candidate genes in dairy cow in response to Escherichia coli mastitis by bioinformatical analysis. Front Genet 10:1251, 2019. Pubmed reference: 31921295. DOI: 10.3389/fgene.2019.01251.
Szyda, J., Mielczarek, M., Frąszczak, M., Minozzi, G., Williams, J.L., Wojdak-Maksymiec, K., Szyda, J., Mielczarek, M., Frąszczak, M., Minozzi, G., Williams, J.L., Wojdak-Maksymiec, K., Szyda, J., Mielczarek, M., Frąszczak, M., Minozzi, G., Williams, J.L., Wojdak-Maksymiec, K. :
The genetic background of clinical mastitis in Holstein-Friesian cattle. Animal 13:2156-2163, 2019. Pubmed reference: 30835192. DOI: 10.1017/S1751731119000338.
Weller, J.I., Ezra, E., van Straten, M. :
Genetic and environmental analysis of diseases with major economic impact in Israeli Holsteins. J Dairy Sci 102:10030-10038, 2019. Pubmed reference: 31521347. DOI: 10.3168/jds.2018-16026.
Yang, L., Guo, R., Ju, Z., Wang, X., Jiang, Q., Liu, Y., Zhao, H., He, K., Li, J., Huang, J. :
Production of an aberrant splice variant of CCL5 is not caused by genetic mutation in the mammary glands of mastitis‑infected Holstein cows. Mol Med Rep 19:4159-4166, 2019. Pubmed reference: 30942444. DOI: 10.3892/mmr.2019.10103.
2018 El-Halawany, N., Shawky, A.A., Al-Tohamy, A.F.M., Abdel-Latif, M.A., Abdel-Shafy, H., Ghazi, Y.A., Neuhoff, C., Schellander, K. :
Effect of complement component 5 polymorphisms on mastitis resistance in Egyptian buffalo and cattle. Res Vet Sci 119:45-51, 2018. Pubmed reference: 29857245. DOI: 10.1016/j.rvsc.2018.05.015.
Martin, P., Barkema, H.W., Brito, L.F., Narayana, S.G., Miglior, F. :
Symposium review: Novel strategies to genetically improve mastitis resistance in dairy cattle. J Dairy Sci :, 2018. Pubmed reference: 29331471. DOI: 10.3168/jds.2017-13554.
Naderi, S., Bohlouli, M., Yin, T., König, S. :
Genomic breeding values, SNP effects and gene identification for disease traits in cow training sets. Anim Genet :, 2018. Pubmed reference: 29624705. DOI: 10.1111/age.12661.
Weigel, K.A., Shook, G.E. :
Genetic Selection for Mastitis Resistance Veterinary Clinics of North America: Food Animal Practice 34:457-472 , 2018. DOI: 10.1016/j.cvfa.2018.07.001.
2017 Mahmoud, M., Yin, T., Brügemann, K., König, S. :
Phenotypic, genetic, and single nucleotide polymorphism marker associations between calf diseases and subsequent performance and disease occurrences of first-lactation German Holstein cows. J Dairy Sci 100:2017-2031, 2017. Pubmed reference: 28109590. DOI: 10.3168/jds.2016-11767.
Ruegg, P.L. :
A 100-Year Review: Mastitis detection, management, and prevention. J Dairy Sci 100:10381-10397, 2017. Pubmed reference: 29153171. DOI: 10.3168/jds.2017-13023.
2016 Tsiamadis, V., Banos, G., Panousis, N., Kritsepi-Konstantinou, M., Arsenos, G., Valergakis, G.E. :
Genetic parameters of subclinical macromineral disorders and major clinical diseases in postparturient Holstein cows. J Dairy Sci 99:8901-8914, 2016. Pubmed reference: 27614830. DOI: 10.3168/jds.2015-10789.
2015 Kadri, N.K., Guldbrandtsen, B., Lund, M.S., Sahana, G. :
Genetic dissection of milk yield traits and mastitis resistance quantitative trait loci on chromosome 20 in dairy cattle. J Dairy Sci 98:9015-25, 2015. Pubmed reference: 26409972. DOI: 10.3168/jds.2015-9599.
2014 Bludau, M.J., Maeschli, A., Leiber, F., Steiner, A., Klocke, P. :
Mastitis in dairy heifers: prevalence and risk factors. Vet J 202:566-72, 2014. Pubmed reference: 25457268. DOI: 10.1016/j.tvjl.2014.09.021.
Liu, X., Wang, Y., Tian, Y., Yu, Y., Gao, M., Hu, G., Su, F., Pan, S., Luo, Y., Guo, Z., Quan, F., Zhang, Y. :
Generation of mastitis resistance in cows by targeting human lysozyme gene to β-casein locus using zinc-finger nucleases. Proc Biol Sci 281:20133368, 2014. Pubmed reference: 24552841. DOI: 10.1098/rspb.2013.3368.
Wang, X., Zhong, J., Gao, Y., Ju, Z., Huang, J. :
A SNP in intron 8 of CD46 causes a novel transcript associated with mastitis in Holsteins. BMC Genomics 15:630, 2014. Pubmed reference: 25070150. DOI: 10.1186/1471-2164-15-630.
2013 Deb, R., Kumar, A., Chakraborty, S., Verma, A.K., Tiwari, R., Dhama, K., Singh, U., Kumar, S. :
Trends in diagnosis and control of bovine mastitis: a review. Pak J Biol Sci 16:1653-61, 2013. Pubmed reference: 24506032.
Haugaard, K., Heringstad, B., Whist, A.C. :
Genetic associations between somatic cell score and pathogen-specific subclinical mastitis in Norwegian Red cows. J Anim Breed Genet 130:98-105, 2013. Pubmed reference: 23496010. DOI: 10.1111/jbg.12019.
Sahana, G., Guldbrandtsen, B., Thomsen, B., Lund, M.S. :
Confirmation and fine-mapping of clinical mastitis and somatic cell score QTL in Nordic Holstein cattle. Anim Genet :, 2013. Pubmed reference: 23647142. DOI: 10.1111/age.12053.
2012 Holmberg, M., Fikse, W.F., Andersson-Eklund, L., Artursson, K., Lundén, A. :
Genetic analyses of pathogen-specific mastitis. J Anim Breed Genet 129:129-37, 2012. Pubmed reference: 22394235. DOI: 10.1111/j.1439-0388.2011.00945.x.
Koeck, A., Miglior, F., Kelton, D.F., Schenkel, F.S. :
Short communication: Genetic parameters for mastitis and its predictors in Canadian Holsteins. J Dairy Sci 95:7363-6, 2012. Pubmed reference: 23021760. DOI: 10.3168/jds.2012-5648.
Meredith, B.K., Kearney, F.J., Finlay, E.K., Bradley, D.G., Fahey, A.G., Berry, D.P., Lynn, D.J. :
Genome-wide associations for milk production and somatic cell score in Holstein-Friesian cattle in Ireland. BMC Genet 13:21, 2012. Pubmed reference: 22449276. DOI: 10.1186/1471-2156-13-21.
Pighetti, G.M., Kojima, C.J., Wojakiewicz, L., Rambeaud, M. :
The bovine CXCR1 gene is highly polymorphic. Vet Immunol Immunopathol 145:464-70, 2012. Pubmed reference: 22056270. DOI: 10.1016/j.vetimm.2011.09.012.
Sørensen, L.P., Janss, L., Madsen, P., Mark, T., Lund, M.S. :
Estimation of (co)variances for genomic regions of flexible sizes: application to complex infectious udder diseases in dairy cattle. Genet Sel Evol 44:18, 2012. Pubmed reference: 22640006. DOI: 10.1186/1297-9686-44-18.
Wijga, S., Bastiaansen, J.W., Wall, E., Strandberg, E., de Haas, Y., Giblin, L., Bovenhuis, H. :
Genomic associations with somatic cell score in first-lactation Holstein cows. J Dairy Sci 95:899-908, 2012. Pubmed reference: 22281354. DOI: 10.3168/jds.2011-4717.
Yuan, Z., Chu, G., Dan, Y., Li, J., Zhang, L., Gao, X., Gao, H., Li, J., Xu, S., Liu, Z. :
BRCA1: a new candidate gene for bovine mastitis and its association analysis between single nucleotide polymorphisms and milk somatic cell score. Mol Biol Rep 39:6625-31, 2012. Pubmed reference: 22327776. DOI: 10.1007/s11033-012-1467-5.
2011 Martins, A.M., Silvestre, A.M., Petim-Batista, M.F., Colaço, J.A. :
Somatic cell score genetic parameter estimates of dairy cattle in Portugal using fractional polynomials. J Anim Sci 89:1281-5, 2011. Pubmed reference: 21521811. DOI: 10.2527/jas.2010-3211.
Mulder, H.A., Lidauer, M.H., Vilkki, J.H., Strandén, I., Veerkamp, R.F. :
Marker-assisted breeding value estimation for mastitis resistance in Finnish Ayrshire cattle. J Dairy Sci 94:4164-73, 2011. Pubmed reference: 21787951. DOI: 10.3168/jds.2010-4112.
2010 Tal-Stein, R., Fontanesi, L., Dolezal, M., Scotti, E., Bagnato, A., Russo, V., Canavesi, F., Friedmann, A., Soller, M., Lipkin, E. :
A genome scan for quantitative trait loci affecting milk somatic cell score in Israeli and Italian Holstein cows by means of selective DNA pooling with single- and multiple-marker mapping. J Dairy Sci 93:4913-27, 2010. Pubmed reference: 20855026. DOI: 10.3168/jds.2010-3254.
Windig, J.J., Ouweltjes, W., Ten Napel, J., de Jong, G., Veerkamp, R.F., De Haas, Y. :
Combining somatic cell count traits for optimal selection against mastitis. J Dairy Sci 93:1690-701, 2010. Pubmed reference: 20338447. DOI: 10.3168/jds.2009-2052.
2009 Detilleux, J.C. :
Genetic factors affecting susceptibility to udder pathogens. Vet Microbiol 134:157-64, 2009. Pubmed reference: 18930606. DOI: 10.1016/j.vetmic.2008.09.023.
Nilsen, H., Olsen, H.G., Hayes, B., Nome, T., Sehested, E., Svendsen, M., Meuwissen, T.H., Lien, S. :
Characterization of a QTL region affecting clinical mastitis and protein yield on BTA6. Anim Genet 40:701-12, 2009. Pubmed reference: 19466933. DOI: 10.1111/j.1365-2052.2009.01908.x.
Schulman, N.F., Sahana, G., Iso-Touru, T., Lund, M.S., Andersson-Eklund, L., Viitala, S.M., Värv, S., Viinalass, H., Vilkki, J.H. :
Fine mapping of quantitative trait loci for mastitis resistance on bovine chromosome 11. Anim Genet 40:509-15, 2009. Pubmed reference: 19397517. DOI: 10.1111/j.1365-2052.2009.01872.x.
Sørensen, L.P., Madsen, P., Mark, T., Lund, M.S. :
Genetic parameters for pathogen-specific mastitis resistance in Danish Holstein Cattle. Animal 3:647-56, 2009. Pubmed reference: 22444442. DOI: 10.1017/S1751731109003899.
2008 Sahana, G., Lund, M.S., Andersson-Eklund, L., Hastings, N., Fernandez, A., Iso-Touru, T., Thomsen, B., Viitala, S., Sørensen, P., Williams, J.L., Vilkki, J. :
Fine-mapping QTL for mastitis resistance on BTA9 in three Nordic red cattle breeds. Anim Genet 39:354-62, 2008. Pubmed reference: 18462482. DOI: 10.1111/j.1365-2052.2008.01729.x.
2007 Heringstad, B., Klemetsdal, G., Steine, T. :
Selection responses for disease resistance in two selection experiments with Norwegian red cows. J Dairy Sci 90:2419-26, 2007. Pubmed reference: 17430946. DOI: 10.3168/jds.2006-805.
Morris, C.A. :
A review of genetic resistance to disease in Bos taurus cattle. Vet J 174:481-91, 2007. Pubmed reference: 17095270. DOI: 10.1016/j.tvjl.2006.09.006.
2006 Zwald, N.R., Weigel, K.A., Chang, Y.M., Welper, R.D., Clay, J.S. :
Genetic analysis of clinical mastitis data from on-farm management software using threshold models. J Dairy Sci 89:330-6, 2006. Pubmed reference: 16357297. DOI: 10.3168/jds.S0022-0302(06)72098-7.
2005 Heringstad, B., Chang, Y.M., Gianola, D., Klemetsdal, G. :
Genetic analysis of clinical mastitis, milk fever, ketosis, and retained placenta in three lactations of Norwegian red cows. J Dairy Sci 88:3273-81, 2005. Pubmed reference: 16107417. DOI: 10.3168/jds.S0022-0302(05)73010-1.
Koivula, M., Mäntysaari, E.A., Negussie, E., Serenius, T. :
Genetic and phenotypic relationships among milk yield and somatic cell count before and after clinical mastitis. J Dairy Sci 88:827-33, 2005. Pubmed reference: 15653550. DOI: 10.3168/jds.S0022-0302(05)72747-8.
Odegård, J., Klemetsdal, G., Heringstad, B. :
Genetic improvement in mastitis resistance: comparison of selection criteria from cross-sectional and random regression sire models for somatic cell score. J Dairy Sci 88:1515-20, 2005. Pubmed reference: 15778321. DOI: 10.3168/jds.S0022-0302(05)72820-4.
Saebø, S., Almøy, T., Heringstad, B., Klemetsdal, G., Aastveit, A.H. :
Genetic evaluation of mastitis resistance using a first-passage time model for wiener processes for analysis of time to first treatment. J Dairy Sci 88:834-41, 2005. Pubmed reference: 15653551. DOI: 10.3168/jds.S0022-0302(05)72748-X.
2004 Saebø, S., Frigessi, A. :
A genetic and spatial Bayesian analysis of mastitis resistance. Genet Sel Evol 36:527-42, 2004. Pubmed reference: 15339631. DOI: 10.1051/gse:2004015.
2003 Heringstad, B., Klemetsdal, G., Steine, T. :
Selection responses for clinical mastitis and protein yield in two Norwegian dairy cattle selection experiments. J Dairy Sci 86:2990-9, 2003. Pubmed reference: 14507036. DOI: 10.3168/jds.S0022-0302(03)73897-1.
Odegård, J., Klemetsdal, G., Heringstad, B. :
Genetic improvement of mastitis resistance: validation of somatic cell score and clinical mastitis as selection criteria. J Dairy Sci 86:4129-36, 2003. Pubmed reference: 14740854. DOI: 10.3168/jds.S0022-0302(03)74027-2.
Rupp, R., Boichard, D. :
Genetics of resistance to mastitis in dairy cattle. Vet Res 34:671-88, 2003. Pubmed reference: 14556700. DOI: 10.1051/vetres:2003020.
2002 Detilleux, J.C. :
Genetic factors affecting susceptibility of dairy cows to udder pathogens. Vet Immunol Immunopathol 88:103-10, 2002. Pubmed reference: 12127409.
1994 Dekkers, J.C., Mallard, B.A., Leslie, K.E. :
Workshop: genetic improvement of resistance to mastitis of dairy cattle with special emphasis on somatic cell count. J Dairy Sci 77:616-8, 1994. Pubmed reference: 7910175.
Shook, G.E., Schutz, M.M. :
Selection on somatic cell score to improve resistance to mastitis in the United States. J Dairy Sci 77:648-58, 1994. Pubmed reference: 8182190. DOI: 10.3168/jds.S0022-0302(94)76995-2.
1989 Shook, G.E. :
Selection for disease resistance. J Dairy Sci 72:1349-62, 1989. Pubmed reference: 2663944. DOI: 10.3168/jds.S0022-0302(89)79242-0.
1987 Vecht, U., Shook, G.E., Politiek, R.D., Grootenhuis, G. :
[Milk cell count as a selection criterion in breeding dairy cattle with improved resistance to mastitis]. Tijdschr Diergeneeskd 112:598-603, 1987. Pubmed reference: 3590134.
1979 Alrawi, A.A., Laben, R.C., Pollak, E.J. :
Genetic analysis of California mastitis test records. II. Score for resistance to elevated tests. J Dairy Sci 62:1125-31, 1979. Pubmed reference: 512135.
1973 Kushner, K.h.F., Velitok, I.G., Sebryakov, E.V., Sergienko, N.A. :
Phenotypic and genetic parameters of the functional characteristics of the udder quarters in cows. IV. Development of udder quarters and resistance of cows to mastitis. Sov Genet 7:1022-9, 1973. Pubmed reference: 4783217.
1966 Mitscherlind, E., Hogreve, F., Koch, J., Scupin, E. :
[Studies on the correlation between the resistance to mastitis and the bloodgrouping factors in Holstein-Frisian cattle]. Dtsch Tierarztl Wochenschr 73:97-102, 1966. Pubmed reference: 6008685.

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  • Created by Frank Nicholas on 25 Nov 2012
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