OMIA 001813-9615 : Haemangiosarcoma in Canis lupus familiaris

In other species: African hunting dog , domestic cat , horse , pig , cattle , sheep , cockatiel , orange-winged amazon parrot

Possibly relevant human trait(s) and/or gene(s) (MIM number): 148000 (trait)

Mendelian trait/disorder: unknown

Considered a defect: yes

Cross-species summary: Hemangiosarcoma


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2021 Evans, J.M., Parker, H.G., Rutteman, G.R., Plassais, J., Grinwis, G.C.M., Harris, A.C., Lana, S.E., Ostrander, E.A. :
Multi-omics approach identifies germline regulatory variants associated with hematopoietic malignancies in retriever dog breeds. PLoS Genet 17:e1009543, 2021. Pubmed reference: 33983928. DOI: 10.1371/journal.pgen.1009543.
Griffin, M.A., Culp, W.T.N., Rebhun, R.B. :
Canine and feline haemangiosarcoma. Vet Rec :e585, 2021. Pubmed reference: 34213807. DOI: 10.1002/vetr.585.
2020 Kim, J.H. :
PIK3CA mutations matter for cancer in dogs. Res Vet Sci 133:39-41, 2020. Pubmed reference: 32932196. DOI: 10.1016/j.rvsc.2020.09.001.
2016 Anwar, S.h., Yanai, T., Sakai, H. :
Overexpression of Peroxiredoxin 6 Protects Neoplastic Cells against Apoptosis in Canine Haemangiosarcoma. J Comp Pathol 155:29-39, 2016. Pubmed reference: 27306414. DOI: 10.1016/j.jcpa.2016.05.002.
Yoo, S., Kim, J., Myung, H.W., Woo, S., Chung, D.J., Lee, A.J., Kim, H.J., DO, S.H., Kim, H.Y. :
Primary intrapelvic hemangiosarcoma in a dog. J Vet Med Sci :, 2016. Pubmed reference: 27746404. DOI: 10.1292/jvms.16-0186.
2015 Tonomura, N., Elvers, I., Thomas, R., Megquier, K., Turner-Maier, J., Howald, C., Sarver, A.L., Swofford, R., Frantz, A.M., Ito, D., Mauceli, E., Arendt, M., Noh, H.J., Koltookian, M., Biagi, T., Fryc, S., Williams, C., Avery, A.C., Kim, J.H., Barber, L., Burgess, K., Lander, E.S., Karlsson, E.K., Azuma, C., Modiano, J.F., Breen, M., Lindblad-Toh, K. :
Genome-wide association study identifies shared risk loci common to two malignancies in golden retrievers. PLoS Genet 11:e1004922, 2015. Pubmed reference: 25642983. DOI: 10.1371/journal.pgen.1004922.
2014 Thomas, R., Borst, L., Rotroff, D., Motsinger-Reif, A., Lindblad-Toh, K., Modiano, J.F., Breen, M. :
Genomic profiling reveals extensive heterogeneity in somatic DNA copy number aberrations of canine hemangiosarcoma. Chromosome Res :, 2014. Pubmed reference: 24599718. DOI: 10.1007/s10577-014-9406-z.
2013 Alvarez, F.J., Hosoya, K., Lara-Garcia, A., Kisseberth, W., Couto, G. :
VAC Protocol for Treatment of Dogs with Stage III Hemangiosarcoma. J Am Anim Hosp Assoc :, 2013. Pubmed reference: 24051260. DOI: 10.5326/JAAHA-MS-5954.
Bellumori, T.P., Famula, T.R., Bannasch, D.L., Belanger, J.M., Oberbauer, A.M. :
Prevalence of inherited disorders among mixed-breed and purebred dogs: 27,254 cases (1995-2010). J Am Vet Med Assoc 242:1549-55, 2013. Pubmed reference: 23683021. DOI: 10.2460/javma.242.11.1549.
Dobson, J.M. :
Breed-predispositions to cancer in pedigree dogs. ISRN Vet Sci 2013:941275, 2013. Pubmed reference: 23738139. DOI: 10.1155/2013/941275.
Tsuji, N., Furukawa, S., Ozaki, K. :
Cutaneous hemangiosarcoma in a dog. J Toxicol Pathol 26:193-5, 2013. Pubmed reference: 23914061. DOI: 10.1293/tox.26.193.
Yamamoto, S., Hoshi, K., Hirakawa, A., Chimura, S., Kobayashi, M., Machida, N. :
Epidemiological, Clinical and Pathological Features of Primary Cardiac Hemangiosarcoma in Dogs: A Review of 51 Cases. J Vet Med Sci :, 2013. Pubmed reference: 23811814.
2012 Asa, S.A., Murai, A., Murakami, M., Hoshino, Y., Mori, T., Maruo, K., Khater, A., El-Sawak, A., el-Aziz, E.A., Yanai, T., Sakai, H. :
Expression of platelet-derived growth factor and its receptors in spontaneous canine hemangiosarcoma and cutaneous hemangioma. Histol Histopathol 27:601-7, 2012. Pubmed reference: 22419024.
Guinan, J., Fischetti, A., Garate, A.P., Chalhoub, S. :
Primary peri-aortic hemangiosarcoma in a dog. Can Vet J 53:1214-8, 2012. Pubmed reference: 23633719.
2011 Haeussler, D.J., Rodríguez, L.M., Wilkie, D.A., Premanandan, C. :
Primary central corneal hemangiosarcoma in a dog. Vet Ophthalmol 14:133-6, 2011. Pubmed reference: 21366830. DOI: 10.1111/j.1463-5224.2010.00849.x.
Mun, A., Lee, E.M., Kim, A.Y., Lee, E.J., Hong, I.H., Jeong, K.S. :
Canine hemangiosarcoma in a female Jindo dog. Lab Anim Res 27:361-3, 2011. Pubmed reference: 22232648. DOI: 10.5625/lar.2011.27.4.361.
Shiu, K.B., Flory, A.B., Anderson, C.L., Wypij, J., Saba, C., Wilson, H., Kurzman, I., Chun, R. :
Predictors of outcome in dogs with subcutaneous or intramuscular hemangiosarcoma. J Am Vet Med Assoc 238:472-9, 2011. Pubmed reference: 21320017. DOI: 10.2460/javma.238.4.472.
2010 Fawcett, A., Phillips, A., Billson, M. :
Ocular hemangiosarcoma in a husky. Compend Contin Educ Vet 32:E8, 2010. Pubmed reference: 23705189.
Tamburini, B.A., Phang, T.L., Fosmire, S.P., Scott, M.C., Trapp, S.C., Duckett, M.M., Robinson, S.R., Slansky, J.E., Sharkey, L.C., Cutter, G.R., Wojcieszyn, J.W., Bellgrau, D., Gemmill, R.M., Hunter, L.E., Modiano, J.F. :
Gene expression profiling identifies inflammation and angiogenesis as distinguishing features of canine hemangiosarcoma. BMC Cancer 10:619, 2010. Pubmed reference: 21062482. DOI: 10.1186/1471-2407-10-619.
2009 Tamburini, B.A., Trapp, S., Phang, T.L., Schappa, J.T., Hunter, L.E., Modiano, J.F. :
Gene expression profiles of sporadic canine hemangiosarcoma are uniquely associated with breed. PLoS One 4:e5549, 2009. Pubmed reference: 19461996. DOI: 10.1371/journal.pone.0005549.
2007 Sargan, D. :
Haemangiosarcoma in German shepherd dogs. Vet Rec 160:672, 2007. Pubmed reference: 17496285.
Yonemaru, K., Sakai, H., Murakami, M., Kodama, A., Mori, T., Yanai, T., Maruo, K., Masegi, T. :
The significance of p53 and retinoblastoma pathways in canine hemangiosarcoma. J Vet Med Sci 69:271-8, 2007. Pubmed reference: 17409643.
2006 Lamerato-Kozicki, A.R., Helm, K.M., Jubala, C.M., Cutter, G.C., Modiano, J.F. :
Canine hemangiosarcoma originates from hematopoietic precursors with potential for endothelial differentiation. Exp Hematol 34:870-8, 2006. Pubmed reference: 16797414. DOI: 10.1016/j.exphem.2006.04.013.
2005 Dickerson, E.B., Thomas, R., Fosmire, S.P., Lamerato-Kozicki, A.R., Bianco, S.R., Wojcieszyn, J.W., Breen, M., Helfand, S.C., Modiano, J.F. :
Mutations of phosphatase and tensin homolog deleted from chromosome 10 in canine hemangiosarcoma. Vet Pathol 42:618-32, 2005. Pubmed reference: 16145208. DOI: 10.1354/vp.42-5-618.
2004 Fosmire, S.P., Dickerson, E.B., Scott, A.M., Bianco, S.R., Pettengill, M.J., Meylemans, H., Padilla, M., Frazer-Abel, A.A., Akhtar, N., Getzy, D.M., Wojcieszyn, J., Breen, M., Helfand, S.C., Modiano, J.F. :
Canine malignant hemangiosarcoma as a model of primitive angiogenic endothelium. Lab Invest 84:562-72, 2004. Pubmed reference: 15064773. DOI: 10.1038/labinvest.3700080.
Schultheiss, P.C. :
A retrospective study of visceral and nonvisceral hemangiosarcoma and hemangiomas in domestic animals. J Vet Diagn Invest 16:522-6, 2004. Pubmed reference: 15586567.
2003 Smith, A.N. :
Hemangiosarcoma in dogs and cats. Vet Clin North Am Small Anim Pract 33:533-52, vi, 2003. Pubmed reference: 12852235.
2002 Mayr, B., Zwetkoff, S., Schaffner, G., Reifinger, M. :
Tumour suppressor gene p53 mutation in a case of haemangiosarcoma of a dog. Acta Vet Hung 50:157-60, 2002. Pubmed reference: 12113170. DOI: 10.1556/AVet.50.2002.2.4.
2001 Clifford, C.A., Hughes, D., Beal, M.W., Mackin, A.J., Henry, C.J., Shofer, F.S., Sorenmo, K.U. :
Plasma vascular endothelial growth factor concentrations in healthy dogs and dogs with hemangiosarcoma. J Vet Intern Med 15:131-5, 2001. Pubmed reference: 11300596.
1998 Wood, C.A., Moore, A.S., Gliatto, J.M., Ablin, L.A., Berg, R.J., Rand, W.M. :
Prognosis for dogs with stage I or II splenic hemangiosarcoma treated by splenectomy alone: 32 cases (1991-1993). J Am Anim Hosp Assoc 34:417-21, 1998. Pubmed reference: 9728473.
1994 Ward, H., Fox, L.E., Calderwood-Mays, M.B., Hammer, A.S., Couto, C.G. :
Cutaneous hemangiosarcoma in 25 dogs: a retrospective study. J Vet Intern Med 8:345-8, 1994. Pubmed reference: 7837111.
1985 Aronsohn, M. :
Cardiac hemangiosarcoma in the dog: a review of 38 cases. J Am Vet Med Assoc 187:922-6, 1985. Pubmed reference: 4055516.
Brown, N.O., Patnaik, A.K., MacEwen, E.G. :
Canine hemangiosarcoma: retrospective analysis of 104 cases. J Am Vet Med Assoc 186:56-8, 1985. Pubmed reference: 4038395.
Ng, C.Y., Mills, J.N. :
Clinical and haematological features of haemangiosarcoma in dogs. Aust Vet J 62:1-4, 1985. Pubmed reference: 4039924.
1978 Oksanen, A. :
Haemangiosarcoma in dogs. J Comp Pathol 88:585-95, 1978. Pubmed reference: 568633.

Edit History

  • Created by Frank Nicholas on 22 May 2013
  • Changed by Imke Tammen2 on 16 Sep 2021