OMIA:001813-9615 : Haemangiosarcoma in Canis lupus familiaris (dog)

In other species: African hunting dog , domestic cat , horse , pig , taurine cattle , sheep , cockatiel , orange-winged amazon parrot

Categories: Neoplasm

Possibly relevant human trait(s) and/or gene(s) (MIM number): 148000 (trait)

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: yes

Cross-species summary: Hemangiosarcoma

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Breeds: Doberman Pinscher (Dog) (VBO_0200442), German Shepherd Dog (Dog) (VBO_0200577), Golden Retriever (Dog) (VBO_0200610).
Breeds in which the phene has been documented. For breeds in which a likely causal variant has been documented, see the variant table below

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:001813-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2023 De Nardi, A.B., de Oliveira Massoco Salles Gomes, C., Fonseca-Alves, C.E., de Paiva, F.N., Linhares, L.C.M., Carra, G.J.U., Dos Santos Horta, R., Ruiz Sueiro, F.A., Jark, P.C., Nishiya, A.T., de Carvalho Vasconcellos, C.H., Ubukata, R., Batschinski, K., Sobral, R.A., Fernandes, S.C., Biondi, L.R., De Francisco Strefezzi, R., Matera, J.M., Rangel, M.M.M., Dos Anjos, D.S., Brunner, C.H.M., Laufer-Amorim, R., Cadrobbi, K.G., Cirillo, J.V., Martins, M.C., de Paula Reis Filho, N., Silva Lessa, D.F., Portela, R., Scarpa Carneiro, C., Ricci Lucas, S.R., Fukumasu, H., Feliciano, M.A.R., Gomes Quitzan, J., Dagli, M.L.Z. :
Diagnosis, prognosis, and treatment of canine hemangiosarcoma: A review based on a consensus organized by the Brazilian Association of Veterinary Oncology, ABROVET. Cancers (Basel) 15:2025, 2023. Pubmed reference: 37046686. DOI: 10.3390/cancers15072025.
Estabrooks, T., Gurinovich, A., Pietruska, J., Lewis, B., Harvey, G., Post, G., Lambert, L., Miller, A., Rodrigues, L., White, M.E., Lopes, C., London, C.A., Megquier, K. :
Identification of genomic alterations with clinical impact in canine splenic hemangiosarcoma. Vet Comp Oncol 21:623-633, 2023. Pubmed reference: 37734854. DOI: 10.1111/vco.12925.
Heishima, K., Aketa, N., Heishima, M., Kawachi, A. :
Hemangiosarcoma in dogs as a potential non-rodent animal model for drug discovery research of angiosarcoma in humans. Front Oncol 13:1250766, 2023. Pubmed reference: 38130992. DOI: 10.3389/fonc.2023.1250766.
Hillman, A., Swafford, B., Delavenne, C., Fieten, H., Boerkamp, K., Tietje, K. :
Descriptive analysis of haemangiosarcoma occurrence in dogs enrolled in the Golden Retriever lifetime study. Vet Comp Oncol 21:700-708, 2023. Pubmed reference: 37635246. DOI: 10.1111/vco.12933.
Kapturska, K.M., Pawlak, A. :
New molecular targets in canine hemangiosarcoma-Comparative review and future of the precision medicine. Vet Comp Oncol 21:357-377, 2023. Pubmed reference: 37308243. DOI: 10.1111/vco.12917.
Klosowski, M., Haines, L., Alfino, L., McMellen, A., Leibowitz, M., Regan, D. :
Naturally occurring canine sarcomas: Bridging the gap from mouse models to human patients through cross-disciplinary research partnerships. Front Oncol 13:1130215, 2023. Pubmed reference: 37035209. DOI: 10.3389/fonc.2023.1130215.
Pimentel, P.A.B., Giuliano, A., Bęczkowski, P.M., Horta, R.D.S. :
Molecular profile of canine hemangiosarcoma and potential novel therapeutic targets. Vet Sci 10:387, 2023. Pubmed reference: 37368773. DOI: 10.3390/vetsci10060387.
Sabattini, S., Baldassarro, V.A., Zaccone, R., Calzà, L., Giardino, L., Vascellari, M., Lorenzini, L., Moretti, M., Marconato, L. :
Dysregulated miRNAs in a canine model of haemangiosarcoma metastatic to the brain. Vet Comp Oncol , 2023. Pubmed reference: 38112225. DOI: 10.1111/vco.12949.
Suzuki, T., Henshaw, M.J., Yanagi, T., Aoshima, K. :
Current understanding of comparative pathology and prospective research approaches for canine hemangiosarcoma. Res Vet Sci 167:S0034-5288(23)00371-5:105120, 2023. Pubmed reference: 38150941. DOI: 10.1016/j.rvsc.2023.105120.
Wade, C.M., Nuttall, R., Liu, S. :
Comprehensive analysis of geographic and breed-purpose influences on genetic diversity and inherited disease risk in the Doberman dog breed. Canine Med Genet 10:7, 2023. Pubmed reference: 37277858. DOI: 10.1186/s40575-023-00130-3.
2021 Evans, J.M., Parker, H.G., Rutteman, G.R., Plassais, J., Grinwis, G.C.M., Harris, A.C., Lana, S.E., Ostrander, E.A. :
Multi-omics approach identifies germline regulatory variants associated with hematopoietic malignancies in retriever dog breeds. PLoS Genet 17:e1009543, 2021. Pubmed reference: 33983928. DOI: 10.1371/journal.pgen.1009543.
Griffin, M.A., Culp, W.T.N., Rebhun, R.B. :
Canine and feline haemangiosarcoma. Vet Rec :e585, 2021. Pubmed reference: 34213807. DOI: 10.1002/vetr.585.
2020 Kim, J.H. :
PIK3CA mutations matter for cancer in dogs. Res Vet Sci 133:39-41, 2020. Pubmed reference: 32932196. DOI: 10.1016/j.rvsc.2020.09.001.
2016 Anwar, S.h., Yanai, T., Sakai, H. :
Overexpression of Peroxiredoxin 6 Protects Neoplastic Cells against Apoptosis in Canine Haemangiosarcoma. J Comp Pathol 155:29-39, 2016. Pubmed reference: 27306414. DOI: 10.1016/j.jcpa.2016.05.002.
Yoo, S., Kim, J., Myung, H.W., Woo, S., Chung, D.J., Lee, A.J., Kim, H.J., DO, S.H., Kim, H.Y. :
Primary intrapelvic hemangiosarcoma in a dog. J Vet Med Sci , 2016. Pubmed reference: 27746404. DOI: 10.1292/jvms.16-0186.
2015 Tonomura, N., Elvers, I., Thomas, R., Megquier, K., Turner-Maier, J., Howald, C., Sarver, A.L., Swofford, R., Frantz, A.M., Ito, D., Mauceli, E., Arendt, M., Noh, H.J., Koltookian, M., Biagi, T., Fryc, S., Williams, C., Avery, A.C., Kim, J.H., Barber, L., Burgess, K., Lander, E.S., Karlsson, E.K., Azuma, C., Modiano, J.F., Breen, M., Lindblad-Toh, K. :
Genome-wide association study identifies shared risk loci common to two malignancies in golden retrievers. PLoS Genet 11:e1004922, 2015. Pubmed reference: 25642983. DOI: 10.1371/journal.pgen.1004922.
2014 Thomas, R., Borst, L., Rotroff, D., Motsinger-Reif, A., Lindblad-Toh, K., Modiano, J.F., Breen, M. :
Genomic profiling reveals extensive heterogeneity in somatic DNA copy number aberrations of canine hemangiosarcoma. Chromosome Res , 2014. Pubmed reference: 24599718. DOI: 10.1007/s10577-014-9406-z.
2013 Alvarez, F.J., Hosoya, K., Lara-Garcia, A., Kisseberth, W., Couto, G. :
VAC Protocol for Treatment of Dogs with Stage III Hemangiosarcoma. J Am Anim Hosp Assoc , 2013. Pubmed reference: 24051260. DOI: 10.5326/JAAHA-MS-5954.
Bellumori, T.P., Famula, T.R., Bannasch, D.L., Belanger, J.M., Oberbauer, A.M. :
Prevalence of inherited disorders among mixed-breed and purebred dogs: 27,254 cases (1995-2010). J Am Vet Med Assoc 242:1549-55, 2013. Pubmed reference: 23683021. DOI: 10.2460/javma.242.11.1549.
Dobson, J.M. :
Breed-predispositions to cancer in pedigree dogs. ISRN Vet Sci 2013:941275, 2013. Pubmed reference: 23738139. DOI: 10.1155/2013/941275.
Tsuji, N., Furukawa, S., Ozaki, K. :
Cutaneous hemangiosarcoma in a dog. J Toxicol Pathol 26:193-5, 2013. Pubmed reference: 23914061. DOI: 10.1293/tox.26.193.
Yamamoto, S., Hoshi, K., Hirakawa, A., Chimura, S., Kobayashi, M., Machida, N. :
Epidemiological, Clinical and Pathological Features of Primary Cardiac Hemangiosarcoma in Dogs: A Review of 51 Cases. J Vet Med Sci , 2013. Pubmed reference: 23811814.
2012 Asa, S.A., Murai, A., Murakami, M., Hoshino, Y., Mori, T., Maruo, K., Khater, A., El-Sawak, A., el-Aziz, E.A., Yanai, T., Sakai, H. :
Expression of platelet-derived growth factor and its receptors in spontaneous canine hemangiosarcoma and cutaneous hemangioma. Histol Histopathol 27:601-7, 2012. Pubmed reference: 22419024.
Guinan, J., Fischetti, A., Garate, A.P., Chalhoub, S. :
Primary peri-aortic hemangiosarcoma in a dog. Can Vet J 53:1214-8, 2012. Pubmed reference: 23633719.
2011 Haeussler, D.J., Rodríguez, L.M., Wilkie, D.A., Premanandan, C. :
Primary central corneal hemangiosarcoma in a dog. Vet Ophthalmol 14:133-6, 2011. Pubmed reference: 21366830. DOI: 10.1111/j.1463-5224.2010.00849.x.
Mun, A., Lee, E.M., Kim, A.Y., Lee, E.J., Hong, I.H., Jeong, K.S. :
Canine hemangiosarcoma in a female Jindo dog. Lab Anim Res 27:361-3, 2011. Pubmed reference: 22232648. DOI: 10.5625/lar.2011.27.4.361.
Shiu, K.B., Flory, A.B., Anderson, C.L., Wypij, J., Saba, C., Wilson, H., Kurzman, I., Chun, R. :
Predictors of outcome in dogs with subcutaneous or intramuscular hemangiosarcoma. J Am Vet Med Assoc 238:472-9, 2011. Pubmed reference: 21320017. DOI: 10.2460/javma.238.4.472.
2010 Fawcett, A., Phillips, A., Billson, M. :
Ocular hemangiosarcoma in a husky. Compend Contin Educ Vet 32:E8, 2010. Pubmed reference: 23705189.
Tamburini, B.A., Phang, T.L., Fosmire, S.P., Scott, M.C., Trapp, S.C., Duckett, M.M., Robinson, S.R., Slansky, J.E., Sharkey, L.C., Cutter, G.R., Wojcieszyn, J.W., Bellgrau, D., Gemmill, R.M., Hunter, L.E., Modiano, J.F. :
Gene expression profiling identifies inflammation and angiogenesis as distinguishing features of canine hemangiosarcoma. BMC Cancer 10:619, 2010. Pubmed reference: 21062482. DOI: 10.1186/1471-2407-10-619.
2009 Tamburini, B.A., Trapp, S., Phang, T.L., Schappa, J.T., Hunter, L.E., Modiano, J.F. :
Gene expression profiles of sporadic canine hemangiosarcoma are uniquely associated with breed. PLoS One 4:e5549, 2009. Pubmed reference: 19461996. DOI: 10.1371/journal.pone.0005549.
2007 Sargan, D. :
Haemangiosarcoma in German shepherd dogs. Vet Rec 160:672, 2007. Pubmed reference: 17496285.
Yonemaru, K., Sakai, H., Murakami, M., Kodama, A., Mori, T., Yanai, T., Maruo, K., Masegi, T. :
The significance of p53 and retinoblastoma pathways in canine hemangiosarcoma. J Vet Med Sci 69:271-8, 2007. Pubmed reference: 17409643.
2006 Lamerato-Kozicki, A.R., Helm, K.M., Jubala, C.M., Cutter, G.C., Modiano, J.F. :
Canine hemangiosarcoma originates from hematopoietic precursors with potential for endothelial differentiation. Exp Hematol 34:870-8, 2006. Pubmed reference: 16797414. DOI: 10.1016/j.exphem.2006.04.013.
2005 Dickerson, E.B., Thomas, R., Fosmire, S.P., Lamerato-Kozicki, A.R., Bianco, S.R., Wojcieszyn, J.W., Breen, M., Helfand, S.C., Modiano, J.F. :
Mutations of phosphatase and tensin homolog deleted from chromosome 10 in canine hemangiosarcoma. Vet Pathol 42:618-32, 2005. Pubmed reference: 16145208. DOI: 10.1354/vp.42-5-618.
2004 Fosmire, S.P., Dickerson, E.B., Scott, A.M., Bianco, S.R., Pettengill, M.J., Meylemans, H., Padilla, M., Frazer-Abel, A.A., Akhtar, N., Getzy, D.M., Wojcieszyn, J., Breen, M., Helfand, S.C., Modiano, J.F. :
Canine malignant hemangiosarcoma as a model of primitive angiogenic endothelium. Lab Invest 84:562-72, 2004. Pubmed reference: 15064773. DOI: 10.1038/labinvest.3700080.
Schultheiss, P.C. :
A retrospective study of visceral and nonvisceral hemangiosarcoma and hemangiomas in domestic animals. J Vet Diagn Invest 16:522-6, 2004. Pubmed reference: 15586567.
2003 Smith, A.N. :
Hemangiosarcoma in dogs and cats. Vet Clin North Am Small Anim Pract 33:533-52, vi, 2003. Pubmed reference: 12852235.
2002 Mayr, B., Zwetkoff, S., Schaffner, G., Reifinger, M. :
Tumour suppressor gene p53 mutation in a case of haemangiosarcoma of a dog. Acta Vet Hung 50:157-60, 2002. Pubmed reference: 12113170. DOI: 10.1556/AVet.50.2002.2.4.
2001 Clifford, C.A., Hughes, D., Beal, M.W., Mackin, A.J., Henry, C.J., Shofer, F.S., Sorenmo, K.U. :
Plasma vascular endothelial growth factor concentrations in healthy dogs and dogs with hemangiosarcoma. J Vet Intern Med 15:131-5, 2001. Pubmed reference: 11300596.
1998 Wood, C.A., Moore, A.S., Gliatto, J.M., Ablin, L.A., Berg, R.J., Rand, W.M. :
Prognosis for dogs with stage I or II splenic hemangiosarcoma treated by splenectomy alone: 32 cases (1991-1993). J Am Anim Hosp Assoc 34:417-21, 1998. Pubmed reference: 9728473.
1994 Ward, H., Fox, L.E., Calderwood-Mays, M.B., Hammer, A.S., Couto, C.G. :
Cutaneous hemangiosarcoma in 25 dogs: a retrospective study. J Vet Intern Med 8:345-8, 1994. Pubmed reference: 7837111.
1985 Aronsohn, M. :
Cardiac hemangiosarcoma in the dog: a review of 38 cases. J Am Vet Med Assoc 187:922-6, 1985. Pubmed reference: 4055516.
Brown, N.O., Patnaik, A.K., MacEwen, E.G. :
Canine hemangiosarcoma: retrospective analysis of 104 cases. J Am Vet Med Assoc 186:56-8, 1985. Pubmed reference: 4038395.
Ng, C.Y., Mills, J.N. :
Clinical and haematological features of haemangiosarcoma in dogs. Aust Vet J 62:1-4, 1985. Pubmed reference: 4039924.
1978 Oksanen, A. :
Haemangiosarcoma in dogs. J Comp Pathol 88:585-95, 1978. Pubmed reference: 568633.

Edit History

  • Created by Frank Nicholas on 22 May 2013
  • Changed by Imke Tammen2 on 16 Sep 2021
  • Changed by Imke Tammen2 on 07 Jun 2023