OMIA 001943-9913 : Fecundity, generic in Bos taurus

In other species: dog , pig , goat , sheep

Category: Reproductive system phene

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: no

Species-specific description: see also OMIA 001022-9913 : Twinning in Bos taurus

History: Morris et al. (2010) reported a mixed-breed cow of uncertain heritage that was named "Treble" on account of her three sets of triplets. Five of the daughters of one her her triplet sons (named "Trio") produced 6 sets of triplets. As concluded by the authors: "Treble is a cow of remarkable reproductive performance, with three sets of triplets. The fact that some of her grand-daughters also produced triplets strongly suggests that some of her ability is inherited."

Mapping: A genome-wide linkage analysis of 131 daughters of the hypothesised carrier bull Trio, each genotyped with 3K SNPs, enabled Kirkpatrick and Morris (2014) to map high ovulation rate (over 4 cycles) to a region of chromosome BTA10. Then, as reported by these same authors, "Haplotype analysis of the sire, recombinant daughters and a subset of non-recombinant daughters using 50k SNP genotype data narrowed the positional candidate region to an area of approximately 1.5 Mb". Kirkpatrick and Morris (2015) narrowed this slightly to "a 1.2 Mb region between 13.6 and 14.8 Mb on chromosome 10".

Genetic testing: Kirkpatrick and Morris (2015) identified "three polymorphisms were identified that can be used as a haplotype to track inheritance of the high ovulation rate allele in descendants of the carrier sire."


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2021 Widmer, S., Seefried, F.R., von Rohr, P., Häfliger, I.M., Spengeler, M., Drögemüller, C. :
A major QTL at the LHCGR/FSHR locus for multiple birth in Holstein cattle. Genet Sel Evol 53:57, 2021. Pubmed reference: 34217202. DOI: 10.1186/s12711-021-00650-1.
2018 Kamalludin, M.H., Garcia-Guerra, A., Wiltbank, M.C., Kirkpatrick, B.W. :
Trio, a novel high fecundity allele: I. Transcriptome analysis of granulosa cells from carriers and noncarriers of a major gene for bovine ovulation rate. Biol Reprod 98:323-334, 2018. Pubmed reference: 29088317. DOI: 10.1093/biolre/iox133.
2015 Kirkpatrick, B.W., Morris, C.A. :
A major gene for bovine ovulation rate. PLoS One 10:e0129025, 2015. Pubmed reference: 26046917. DOI: 10.1371/journal.pone.0129025.
2014 Kirkpatrick, B.W., Morris, C.A. :
Mapping of a major gene for bovine ovulation rate. 10th World Congress on Genetics Applied to Livestock Production (WCGALP) :Abstract 649, 2014.
2010 Morris, C.A., Wheeler, M., Levet, G.L., Kirkpatrick, B.W. :
A cattle family in New Zealand with triplet calving ability. Livestock Science 128:193-196, 2010.

Edit History

  • Created by Frank Nicholas on 17 Nov 2014
  • Changed by Frank Nicholas on 17 Nov 2014
  • Changed by Frank Nicholas on 26 Apr 2016
  • Changed by Imke Tammen2 on 08 Aug 2021