OMIA 001943-9940 : Fecundity, generic in Ovis aries

In other species: dog , cattle , goat

Mendelian trait/disorder: unknown

Considered a defect: no

Species-specific description: Several genes and alleles have been identified to impact fecundity/litter size in sheep and are listed as separate entries in OMIA. Any reference related to fecundity that are not related to these known genes or alleles are listed here.

Mapping: Kang et al. (2021) "hypothesized that the polymorphisms of KDM3B gene were associated with sheep reproduction traits. A 7-nt nucleotide sequence variant (rs1088697156) within KDM3Bgene was identified in a total of 888 individuals, including the Australian White (AUW) sheep and Lanzhou Fat-tailed (LFT) sheep. II (insertion/insertion) and ID (insertion/deletion) genotypes of 7-nt variant were detected, which were at Hardy-Weinberg equilibrium (HWE) in detected breeds. Association analysis illustrated the 7-nt variant was significantly associated with the littersize, duration of pregnancy, live lamb number, live lamb rate, stillbirth number, stillbirth rate of average and different parity (P<0.05) in AUW sheep. Moreover, ‘ID’ was the dominant genotype with excellent consistency in reproductive traits."

Li et al. (2021) "explored potential polymorphisms of the sheep TSHR gene, and a 29 bp nucleotide sequence variant (rs1089565492) was identified in the AUW sheep. ... Association analysis results showed the 29 bp variant was significantly associated with the litter size of the AUW sheep (p < 0.05)."

Associated genes:

Symbol Description Species Chr Location OMIA gene details page Other Links
TSHR thyroid stimulating hormone receptor Ovis aries 7 NC_056060.1 (90438630..90610132) TSHR Homologene, Ensembl, NCBI gene
KDM3B lysine (K)-specific demethylase 3B Ovis aries 5 NC_056058.1 (47420434..47479316) KDM3B Homologene, Ensembl, NCBI gene

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2021 Kang, Y., Bi, Y., Tang, Q., Xu, H., Lan, X., Zhang, Q., Pan, C. :
KDM3B gene affects female reproduction traits. Anim Biotechnol :1-7, 2021. Pubmed reference: 34081570. DOI: 10.1080/10495398.2021.1929270.
Li, M., Zhou, Q., Pan, Y., Lan, X., Zhang, Q., Pan, C., Mao, C. :
Screen of small fragment mutations within the sheep thyroid stimulating hormone receptor gene associated with litter size. Anim Biotechnol :1-6, 2021. Pubmed reference: 34895066. DOI: 10.1080/10495398.2021.1992415.
Salehian-Dehkordi, H., Xu, Y.X., Xu, S.S., Li, X., Luo, L.Y., Liu, Y.J., Wang, D.F., Cao, Y.H., Shen, M., Gao, L., Chen, Z.H., Glessner, J.T., Lenstra, J.A., Esmailizadeh, A., Li, M.H., Lv, F.H. :
Genome-wide detection of copy number variations and their association with distinct phenotypes in the world's sheep. Front Genet 12:670582, 2021. Pubmed reference: 34093663. DOI: 10.3389/fgene.2021.670582.
Tao, L., Wang, X., Zhong, Y., Liu, Q., Xia, Q., Chen, S., He, X., Di, R., Chu, M. :
Combined approaches identify known and novel genes associated with sheep litter size and non-seasonal breeding. Anim Genet 52:857-867, 2021. Pubmed reference: 34494299. DOI: 10.1111/age.13138.
2019 Dolebo, A.T., Khayatzadeh, N., Melesse, A., Wragg, D., Rekik, M., Haile, A., Rischkowsky, B., Rothschild, M.F., Mwacharo, J.M. :
Genome-wide scans identify known and novel regions associated with prolificacy and reproduction traits in a sub-Saharan African indigenous sheep (Ovis aries). Mamm Genome 30:339-352, 2019. Pubmed reference: 31758253. DOI: 10.1007/s00335-019-09820-5.
Ma, H., Fang, C., Liu, L., Wang, Q., Aniwashi, J., Sulaiman, Y., Abudilaheman, K., Liu, W. :
Identification of novel genes associated with litter size of indigenous sheep population in Xinjiang, China using specific-locus amplified fragment sequencing technology. PeerJ 7:e8079, 2019. Pubmed reference: 31788357. DOI: 10.7717/peerj.8079.
2005 Bi, XD., Chu, MX., Jin, HG., Fang, L., Ye, SC. :
[Estrogen receptor as a candidate gene for prolificacy of small tail Han sheep] Yi Chuan Xue Bao 32:1060-5, 2005. Pubmed reference: 16252701.

Edit History


  • Created by Frank Nicholas on 19 Jun 2020
  • Changed by Imke Tammen2 on 16 Jun 2021
  • Changed by Imke Tammen2 on 17 Jun 2021
  • Changed by Imke Tammen2 on 30 Jan 2022