OMIA:002063-9615 : Hyperlipidaemia/atherosclerosis, APOE-related in Canis lupus familiaris (dog)

In other species: pig , rabbit

Categories: Homeostasis / metabolism phene

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 107741 (gene) , 617347 (trait)

Links to MONDO diseases: No links.

Mendelian trait/disorder: yes

Considered a defect: no

Key variant known: yes

Year key variant first reported: 2021

Species-specific description: Zhao et al. (2021) "report hypercholesterolemia [hypercholesterolaemia] and severe atherosclerosis characterized by stenosis and occlusion of arteries, together with clinical manifestations of stroke and gangrene, in ApoE knockout dogs generated by CRISPR/Cas9 and cloned by somatic cell nuclear transfer technologies." This study involves genetically modified organisms (GMO).

Genetic engineering: Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
APOE apolipoprotein E Canis lupus familiaris 1 NC_051805.1 (111058288..111055483) APOE Homologene, Ensembl , NCBI gene

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:002063-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2023 Zhao, H., Liu, E., Zhang, Y.Q. :
Dog models of human atherosclerotic cardiovascular diseases. Mamm Genome 34:262-269, 2023. Pubmed reference: 36243810. DOI: 10.1007/s00335-022-09965-w.
2022 Jia, L., Li, Y., Hua, Y., Liu, Y., Zhang, N., Gao, M., Zhang, K., Li, J., Mi, J., Zhang, J., Jiao, S. :
Identification of the atherosclerosis phenotype in vivo by vascular duplex ultrasonography in ApoE-deficient dogs. Atherosclerosis Plus 47:8-15, 2022.
Zhao, H., Zhao, J., Wu, D., Sun, Z., Hua, Y., Zheng, M., Liu, Y., Yang, Q., Huang, X., Li, Y., Piao, Y., Wang, Y., Lam, S.M., Xu, H., Shui, G., Wang, Y., Yao, H., Lai, L., Du, Z., Mi, J., Liu, E., Ji, X., Zhang, Y.Q. :
Dogs lacking Apolipoprotein E show advanced atherosclerosis leading to apparent clinical complications. Sci China Life Sci 65:1342-1356, 2022. Pubmed reference: 34705220. DOI: 10.1007/s11427-021-2006-y.
2018 Feng, C., Wang, X., Shi, H., Yan, Q., Zheng, M., Li, J., Zhang, Q., Qin, Y., Zhong, Y., Mi, J., Lai, L. :
Generation of ApoE deficient dogs via combination of embryo injection of CRISPR/Cas9 with somatic cell nuclear transfer. J Genet Genomics 45:47-50, 2018. Pubmed reference: 29396142. DOI: 10.1016/j.jgg.2017.11.003.

Edit History

  • Created by Imke Tammen2 on 03 Nov 2021
  • Changed by Imke Tammen2 on 10 Nov 2022
  • Changed by Imke Tammen2 on 17 May 2023
  • Changed by Imke Tammen2 on 18 Dec 2023