OMIA:002063-9615 : Hyperlipidaemia/atherosclerosis, APOE-related in Canis lupus familiaris

In other species: pig , rabbit

Categories: Homeostasis / metabolism phene

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 107741 (gene) , 617347 (trait)

Links to MONDO diseases: No links.

Mendelian trait/disorder: yes

Considered a defect: no

Key variant known: yes

Year key variant first reported: 2021

Species-specific description: Zhao et al. (2021) "report hypercholesterolemia and severe atherosclerosis characterized by stenosis and occlusion of arteries, together with clinical manifestations of stroke and gangrene, in ApoE knockout dogs generated by CRISPR/Cas9 and cloned by somatic cell nuclear transfer technologies."

This study involves genetically modified organisms (GMO).

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
APOE apolipoprotein E Canis lupus familiaris 1 NC_051805.1 (111058288..111055483) APOE Homologene, Ensembl , NCBI gene


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2022 Jia, L., Li, Y., Hua, Y., Liu, Y., Zhang, N., Gao, M., Zhang, K., Li, J., Mi, J., Zhang, J., Jiao, S. :
Identification of the atherosclerosis phenotype in vivo by vascular duplex ultrasonography in ApoE-deficient dogs. Atherosclerosis Plus 47:8-15, 2022.
Zhao, H., Zhao, J., Wu, D., Sun, Z., Hua, Y., Zheng, M., Liu, Y., Yang, Q., Huang, X., Li, Y., Piao, Y., Wang, Y., Lam, S.M., Xu, H., Shui, G., Wang, Y., Yao, H., Lai, L., Du, Z., Mi, J., Liu, E., Ji, X., Zhang, Y.Q. :
Dogs lacking Apolipoprotein E show advanced atherosclerosis leading to apparent clinical complications. Sci China Life Sci 65:1342-1356, 2022. Pubmed reference: 34705220 . DOI: 10.1007/s11427-021-2006-y.
Zhao, H., Liu, E., Zhang, Y.Q. :
Dog models of human atherosclerotic cardiovascular diseases. Mamm Genome :, 2022. Pubmed reference: 36243810 . DOI: 10.1007/s00335-022-09965-w.
2018 Feng, C., Wang, X., Shi, H., Yan, Q., Zheng, M., Li, J., Zhang, Q., Qin, Y., Zhong, Y., Mi, J., Lai, L. :
Generation of ApoE deficient dogs via combination of embryo injection of CRISPR/Cas9 with somatic cell nuclear transfer. J Genet Genomics 45:47-50, 2018. Pubmed reference: 29396142 . DOI: 10.1016/j.jgg.2017.11.003.

Edit History

  • Created by Imke Tammen2 on 03 Nov 2021
  • Changed by Imke Tammen2 on 10 Nov 2022