OMIA 002063-9615 : Hyperlipidaemia/atherosclerosis, APOE-related in Canis lupus familiaris |
In other species:
pig
,
rabbit
Possibly relevant human trait(s) and/or gene(s)s (MIM numbers):
107741 (gene)
,
617347 (trait)
Mendelian trait/disorder:
yes
Considered a defect:
no
Key variant known:
yes
Year key variant first reported:
2021
Species-specific description:
Zhao et al. (2021) "report hypercholesterolemia and severe atherosclerosis characterized by stenosis and occlusion of arteries, together with clinical manifestations of stroke and gangrene, in ApoE knockout dogs generated by CRISPR/Cas9 and cloned by somatic cell nuclear transfer technologies."
This study involves genetically modified organisms (GMO).
Associated gene:| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| APOE | apolipoprotein E | Canis lupus familiaris | 1 | NC_051805.1 (111058288..111055483) | APOE | Homologene, Ensembl, NCBI gene |
Reference
| 2021 | Zhao, H., Zhao, J., Wu, D., Sun, Z., Hua, Y., Zheng, M., Liu, Y., Yang, Q., Huang, X., Li, Y., Piao, Y., Wang, Y., Lam, S.M., Xu, H., Shui, G., Wang, Y., Yao, H., Lai, L., Du, Z., Mi, J., Liu, E., Ji, X., Zhang, Y.Q. : | |
| Dogs lacking Apolipoprotein E show advanced atherosclerosis leading to apparent clinical complications. Sci China Life Sci :, 2021. Pubmed reference: 34705220. DOI: 10.1007/s11427-021-2006-y. |
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- Created by Imke Tammen2 on 03 Nov 2021