OMIA:002063-9986 : Hyperlipidaemia/atherosclerosis, APOE-related in Oryctolagus cuniculus (rabbit)

In other species: dog , pig

Categories: Homeostasis / metabolism phene

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 107741 (gene) , 617347 (trait)

Links to MONDO diseases: No links.

Mendelian trait/disorder: yes

Considered a defect: yes

Key variant known: yes

Year key variant first reported: 2016

Species-specific description: This is a genetically-modified organism (GMO)

Genetic engineering: Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
APOE apolipoprotein E Oryctolagus cuniculus NW_026257127.1 (186735..184211) APOE Homologene, Ensembl , NCBI gene

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:002063-9986: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2021 Zhang, Y., Fatima, M., Hou, S., Bai, L., Zhao, S., Liu, E. :
Research methods for animal models of atherosclerosis (Review). Mol Med Rep 24:871, 2021. Pubmed reference: 34713295. DOI: 10.3892/mmr.2021.12511.
2020 Poznyak, A.V., Silaeva, Y.Y., Orekhov, A.N., Deykin, A.V. :
Animal models of human atherosclerosis: current progress. Braz J Med Biol Res 53:e9557, 2020. Pubmed reference: 32428130. DOI: 10.1590/1414-431x20209557.
Zabriskie, M.S., Wang, C., Wang, S., Alexander, M.D. :
Apolipoprotein E knockout rabbit model of intracranial atherosclerotic disease. Animal Model Exp Med 3:208-213, 2020. Pubmed reference: 32613180. DOI: 10.1002/ame2.12125.
2016 Niimi, M., Yang, D., Kitajima, S., Ning, B., Wang, C., Li, S., Liu, E., Zhang, J., Eugene Chen, Y., Fan, J. :
ApoE knockout rabbits: A novel model for the study of human hyperlipidemia. Atherosclerosis 245:187-93, 2016. Pubmed reference: 26724529. DOI: 10.1016/j.atherosclerosis.2015.12.002.

Edit History

  • Created by Frank Nicholas on 28 Oct 2016
  • Changed by Imke Tammen2 on 03 Nov 2021
  • Changed by Imke Tammen2 on 18 Dec 2023