OMIA:002063-9986 : Hyperlipidaemia/atherosclerosis, APOE-related in Oryctolagus cuniculus (rabbit) |
Categories: Homeostasis / metabolism phene
Links to possible relevant human trait(s) and/or gene(s) in OMIM: 107741 (gene) , 617347 (trait)
Mendelian trait/disorder: yes
Disease-related: yes
Key variant known: yes
Year key variant first reported: 2016
Species-specific description: This is a genetically-modified organism (GMO)
Genetic engineering:
Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| APOE | apolipoprotein E | Oryctolagus cuniculus | NW_026257127.1 (186735..184211) | APOE | Homologene, Ensembl , NCBI gene |
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:002063-9986: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2024 | Niimi, M., Chen, Y., Zhao, H., Tang, X., Matsuhisa, F., Zhou, H., Yan, H., Chen, L., Kitajima, S., Sato, A., Fan, J. : |
| Enhanced atherosclerosis in apolipoprotein E knockout rabbits: role of apoB48-rich remnant lipoproteins. Front Cardiovasc Med 11:1424064, 2024. Pubmed reference: 39087075. DOI: 10.3389/fcvm.2024.1424064. | |
| 2021 | Zhang, Y., Fatima, M., Hou, S., Bai, L., Zhao, S., Liu, E. : |
| Research methods for animal models of atherosclerosis (Review). Mol Med Rep 24:871, 2021. Pubmed reference: 34713295. DOI: 10.3892/mmr.2021.12511. | |
| 2020 | Poznyak, A.V., Silaeva, Y.Y., Orekhov, A.N., Deykin, A.V. : |
| Animal models of human atherosclerosis: current progress. Braz J Med Biol Res 53:e9557, 2020. Pubmed reference: 32428130. DOI: 10.1590/1414-431x20209557. | |
| Zabriskie, M.S., Wang, C., Wang, S., Alexander, M.D. : | |
| Apolipoprotein E knockout rabbit model of intracranial atherosclerotic disease. Animal Model Exp Med 3:208-213, 2020. Pubmed reference: 32613180. DOI: 10.1002/ame2.12125. | |
| 2016 | Niimi, M., Yang, D., Kitajima, S., Ning, B., Wang, C., Li, S., Liu, E., Zhang, J., Eugene Chen, Y., Fan, J. : |
| ApoE knockout rabbits: A novel model for the study of human hyperlipidemia. Atherosclerosis 245:187-93, 2016. Pubmed reference: 26724529. DOI: 10.1016/j.atherosclerosis.2015.12.002. |
Edit History
- Created by Frank Nicholas on 28 Oct 2016
- Changed by Imke Tammen2 on 03 Nov 2021
- Changed by Imke Tammen2 on 18 Dec 2023