OMIA:002328-9483 : Behaviour in Callithrix jacchus

In other species: dog , domestic cat , chicken , horse , , pig

Categories: Behaviour / neurological phene

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: unknown

Species-specific description: Popa et al. (2022) "revealed that marmosets bearing different SLC6A4 variants exhibit distinct microRNAs signatures in a region of the prefrontal cortex whose activity has been consistently altered in patients with depression/anxiety. We also identified Deleted in Colorectal Cancer (DCC), a gene previously linked to these diseases, as a downstream target of the differently expressed microRNAs. Significantly, we showed that levels of both microRNAs and DCC in this region were highly correlated to anxiety-like behaviors."

Reference

2022 Popa, N., Bachar, D., Roberts, A.C., Santangelo, A.M., Gascon, E. :
Region-specific microRNA alterations in marmosets carrying SLC6A4 polymorphisms are associated with anxiety-like behavior. EBioMedicine 82:104159, 2022. Pubmed reference: 35905539 . DOI: 10.1016/j.ebiom.2022.104159.

Edit History


  • Changed by Imke Tammen2 on 13 Jan 2023
  • Created by Imke Tammen2 on 13 Jan 2023