OMIA:002353-8782 : Limb movement, synchronic, EFNB3-related in Aves

In other species: fowls , chicken , turkey , Japanese quail

Categories: Limbs / digit / tail phene

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: no

Cross-species summary: "Flight in birds evolved through patterning of the wings from forelimbs and transition from alternating gait to synchronous flapping. In mammals, the spinal midline guidance molecule ephrin-B3 [EFNB3] instructs the wiring that enables limb alternation, and its deletion leads to synchronous hopping gait." (Haimson et al. 2021)

Species-specific description: Haimson et al. (2021) "show that the ephrin-B3 protein in birds lacks several motifs present in other vertebrates, diminishing its affinity for the EphA4 receptor. The avian ephrin-B3 gene [EFNB3] lacks an enhancer that drives midline expression and is missing in galliforms."


2021 Haimson, B., Meir, O., Sudakevitz-Merzbach, R., Elberg, G., Friedrich, S., Lovell, P.V., Paix√£o, S., Klein, R., Mello, C.V., Klar, A. :
Natural loss of function of ephrin-B3 shapes spinal flight circuitry in birds. Sci Adv 7:, 2021. Pubmed reference: 34117069 . DOI: 10.1126/sciadv.abg5968.

Edit History

  • Created by Imke Tammen2 on 17 Jun 2021
  • Changed by Imke Tammen2 on 17 Jun 2021