OMIA:002353-93934 : Limb movement, synchronic, EFNB3-related in Coturnix japonica (Japanese quail)

In other species: birds , fowls , chicken , turkey

Categories: Limbs / fins / digit / tail phene

Mendelian trait/disorder: unknown

Considered a defect: no

Cross-species summary: "Flight in birds evolved through patterning of the wings from forelimbs and transition from alternating gait to synchronous flapping. In mammals, the spinal midline guidance molecule ephrin-B3 [EFNB3] instructs the wiring that enables limb alternation, and its deletion leads to synchronous hopping gait." (Haimson et al. 2021)

Species-specific description: Haimson et al. (2021) "show that the ephrin-B3 protein in birds lacks several motifs present in other vertebrates, diminishing its affinity for the EphA4 receptor. The avian ephrin-B3 gene [EFNB3] lacks an enhancer that drives midline expression and is missing in galliforms."

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2021). OMIA:002353-93934: Online Mendelian Inheritance in Animals (OMIA) [dataset].


2021 Haimson, B., Meir, O., Sudakevitz-Merzbach, R., Elberg, G., Friedrich, S., Lovell, P.V., Paix√£o, S., Klein, R., Mello, C.V., Klar, A. :
Natural loss of function of ephrin-B3 shapes spinal flight circuitry in birds. Sci Adv 7:eabg5968, 2021. Pubmed reference: 34117069. DOI: 10.1126/sciadv.abg5968.

Edit History

  • Created by Imke Tammen2 on 17 Jun 2021
  • Changed by Imke Tammen2 on 17 Jun 2021