OMIA:002630-461223 : Tolerance to batrachotoxin (BTX) in Pitohui ferrugineus
In other species: , , blue-capped ifrita , , rufous-naped whistler , Black pitohui
Categories: Nervous system phene , Muscle phene
Links to MONDO diseases: No links.
Mendelian trait/disorder: unknown
Considered a defect: no
Cross-species summary: Batrachotoxin (BTX) is a cardio- and neurotoxic steroidal alkaloid found in beetles, birds and frogs. BTX binds to voltage-gated sodium ion channels (coded for by SCN genes), leading to muscle paralysis and death. Several species of animals with a tolerance or auto-resistance to BTX, acquire BTX in their diet and transport BTX to their skin and/or feathers as a defence mechanism or possible parasite deterrence.
|2023||Bodawatta, K.H., Hu, H., Schalk, F., Daniel, J.M., Maiah, G., Koane, B., Iova, B., Beemelmanns, C., Poulsen, M., Jønsson, K.A. :|
|Multiple mutations in the Nav1.4 sodium channel of New Guinean toxic birds provide auto-resistance to deadly batrachotoxin. Mol Ecol :, 2023. Pubmed reference: 36779590 . DOI: 10.1111/mec.16878.|
- Created by Imke Tammen2 on 17 Feb 2023