OMIA:002630-51961 : Tolerance to batrachotoxin (BTX) in Phyllobates (poison dart frogs) |
In other species: regent whistler , hooded pitohui , rufous-naped whistler , rusty pitohui , black pitohui , blue-capped ifrita
Categories: Nervous system phene , Muscle phene
Links to MONDO diseases: No links.
Mendelian trait/disorder: unknown
Considered a defect: no
Cross-species summary: Batrachotoxin (BTX) is a cardio- and neurotoxic steroidal alkaloid found in beetles, birds and frogs. BTX binds to voltage-gated sodium ion channels (coded for by SCN genes), leading to muscle paralysis and death. Several species of animals with a tolerance or auto-resistance to BTX, acquire BTX in their diet and transport BTX to their skin and/or feathers as a defence mechanism or possible parasite deterrence.
Genetic engineering:
Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:002630-51961: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2017 | Wang, S.Y., Wang, G.K. : |
| Single rat muscle Na<sup>+</sup> channel mutation confers batrachotoxin autoresistance found in poison-dart frog <i>Phyllobates terribilis</i>. Proc Natl Acad Sci U S A 114:10491-10496, 2017. Pubmed reference: 28874544. DOI: 10.1073/pnas.1707873114. | |
| 1980 | Daly, J.W., Myers, C.W., Warnick, J.E., Albuquerque, E.X. : |
| Levels of batrachotoxin and lack of sensitivity to its action in poison-dart frogs (Phyllobates). Science 208:1383-5, 1980. Pubmed reference: 6246586. DOI: 10.1126/science.6246586. |
Edit History
- Created by Imke Tammen2 on 17 Feb 2023
- Changed by Imke Tammen2 on 17 Feb 2023
- Changed by Imke Tammen2 on 20 Sep 2023