OMIA:002630-156166 : Tolerance to batrachotoxin (BTX) in Pitohui dichrous

In other species: , blue-capped ifrita , , rufous-naped whistler , Rusty pitohui , Black pitohui

Categories: Nervous system phene , Muscle phene

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: no

Cross-species summary: Batrachotoxin (BTX) is a cardio- and neurotoxic steroidal alkaloid found in beetles, birds and frogs. BTX binds to voltage-gated sodium ion channels (coded for by SCN genes), leading to muscle paralysis and death. Several species of animals with a tolerance or auto-resistance to BTX, acquire BTX in their diet and transport BTX to their skin and/or feathers as a defence mechanism or possible parasite deterrence.


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2023 Bodawatta, K.H., Hu, H., Schalk, F., Daniel, J.M., Maiah, G., Koane, B., Iova, B., Beemelmanns, C., Poulsen, M., J√łnsson, K.A. :
Multiple mutations in the Nav1.4 sodium channel of New Guinean toxic birds provide auto-resistance to deadly batrachotoxin. Mol Ecol :, 2023. Pubmed reference: 36779590 . DOI: 10.1111/mec.16878.
1992 Dumbacher, J.P., Beehler, B.M., Spande, T.F., Garraffo, H.M., Daly, J.W. :
Homobatrachotoxin in the genus Pitohui: chemical defense in birds? Science 258:799-801, 1992. Pubmed reference: 1439786 . DOI: 10.1126/science.1439786.

Edit History

  • Created by Imke Tammen2 on 17 Feb 2023
  • Changed by Imke Tammen2 on 17 Feb 2023