OMIA:002630-156166 : Tolerance to batrachotoxin (BTX) in Pitohui dichrous (hooded pitohui) |
In other species: poison dart frogs , regent whistler , rufous-naped whistler , rusty pitohui , black pitohui , blue-capped ifrita
Categories: Nervous system phene , Muscle phene
Links to MONDO diseases: No links.
Mendelian trait/disorder: unknown
Considered a defect: no
Cross-species summary: Batrachotoxin (BTX) is a cardio- and neurotoxic steroidal alkaloid found in beetles, birds and frogs. BTX binds to voltage-gated sodium ion channels (coded for by SCN genes), leading to muscle paralysis and death. Several species of animals with a tolerance or auto-resistance to BTX, acquire BTX in their diet and transport BTX to their skin and/or feathers as a defence mechanism or possible parasite deterrence.
Genetic engineering:
Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:002630-156166: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2023 | Bodawatta, K.H., Hu, H., Schalk, F., Daniel, J.M., Maiah, G., Koane, B., Iova, B., Beemelmanns, C., Poulsen, M., Jønsson, K.A. : |
| Multiple mutations in the Nav1.4 sodium channel of New Guinean toxic birds provide auto-resistance to deadly batrachotoxin. Mol Ecol , 2023. Pubmed reference: 36779590. DOI: 10.1111/mec.16878. | |
| 1992 | Dumbacher, J.P., Beehler, B.M., Spande, T.F., Garraffo, H.M., Daly, J.W. : |
| Homobatrachotoxin in the genus Pitohui: chemical defense in birds? Science 258:799-801, 1992. Pubmed reference: 1439786. DOI: 10.1126/science.1439786. |
Edit History
- Created by Imke Tammen2 on 17 Feb 2023
- Changed by Imke Tammen2 on 17 Feb 2023
- Changed by Imke Tammen2 on 20 Sep 2023