OMIA:002660-9823 : Resistance/susceptibility to avian influenza virus in Sus scrofa (pig)

In other species: Mallard , chicken

Categories: Immune system phene

Single-gene trait/disorder: unknown

Disease-related: yes

Molecular basis: Kwon et al. (2024) "aimed to determine the effects of TMPRSS2 on the replication of pandemic H1N1 and H3N2 subtype IAVs in the natural host, the pig. The use of the CRISPR/Cas 9 system led to the establishment of homozygous gene edited (GE) TMPRSS2 knockout (KO) pigs. Delayed IAV replication was demonstrated in primary respiratory cells of KO pigs in vitro. IAV infection in vivo resulted in significant reduction of virus shedding in the upper respiratory tract, and lower virus titers and pathological lesions in the lower respiratory tract of TMPRSS2 KO pigs as compared to WT pigs." This study involves genetically modified organisms (GMO).

Genetic engineering: Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
TMPRSS2 transmembrane serine protease 2 Sus scrofa 13 NC_010455.5 (204905411..204874759) TMPRSS2 Homologene, Ensembl , NCBI gene

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2024). OMIA:002660-9823: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2024 Kwon, T., Artiaga, B.L., McDowell, C.D., Whitworth, K.M., Wells, K.D., Prather, R.S., Delhon, G., Cigan, M., White, S.N., Retallick, J., Gaudreault, N.N., Morozov, I., Richt, J.A. :
Gene editing of pigs to control influenza A virus infections. bioRxiv , 2024. Pubmed reference: 38293027. DOI: 10.1101/2024.01.15.575771.
Kwon, T., Artiaga, B.L., McDowell, C.D., Whitworth, K.M., Wells, K.D., Prather, R.S., Delhon, G., Cigan, M., White, S.N., Retallick, J., Gaudreault, N.N., Morozov, I., Richt, J.A. :
Gene editing of pigs to control influenza A virus infections. Emerg Microbes Infect 13:2387449, 2024. Pubmed reference: 39083026. DOI: 10.1080/22221751.2024.2387449.
2023 Ciacci Zanella, G., Snyder, C.A., Arruda, B.L., Whitworth, K., Green, E., Poonooru, R.R., Telugu, B.P., Baker, A.L. :
Pigs lacking TMPRSS2 displayed fewer lung lesions and reduced inflammatory response when infected with influenza A virus. Front Genome Ed 5:1320180, 2023. Pubmed reference: 38883409. DOI: 10.3389/fgeed.2023.1320180.

Edit History


  • Created by Imke Tammen2 on 03 May 2024
  • Changed by Imke Tammen2 on 03 May 2024