Gene TP53 : tumor protein p53 in Sus scrofa

See the equivalent entry at NCBI

In other species: dog , crab-eating macaque

Symbol: TP53

Synonyms: P53

Description: tumor protein p53

Type of gene: protein-coding

Comment: Using transgenesis of mesenchymal stem cells, followed by somatic cell nuclear transfer, Leuchs et al. (2012) created cloned pigs heterozygous for "a latent TP53(R167H) mutant allele, orthologous to oncogenic human mutant TP53(R175H) and mouse Trp53(R172H), that can be activated by Cre recombination . . . which represents the first inactivation and mutation of the gatekeeper tumor suppressor gene TP53 in a non-rodent mammal".

NCBI gene id: 397276

Other designations: cellular tumor antigen p53|tumor suppressor p53

Links: Homologene , Ensembl

Genomic location: 12:52953786..52939643 [Chromosome accession NC_010454.4]

Related phenes:

OMIA:001990-9823 : Cancer, TP53-related in Sus scrofa


2012 Leuchs, S., Saalfrank, A., Merkl, C., Flisikowska, T., Edlinger, M., Durkovic, M., Rezaei, N., Kurome, M., Zakhartchenko, V., Kessler, B., Flisikowski, K., Kind, A., Wolf, E., Schnieke, A. :
Inactivation and inducible oncogenic mutation of p53 in gene targeted pigs. PLoS One 7:e43323, 2012. Pubmed reference: 23071491. DOI: 10.1371/journal.pone.0043323.

Edit History

  • Changed by Frank Nicholas on 04 May 2013