OMIA:000299-9823 : Dwarfism, generic in Sus scrofa (pig)

In other species: white-tufted-ear marmoset , dog , domestic cat , Asiatic elephant , horse , red deer , Northern giraffe , taurine cattle , indicine cattle (zebu) , goat , sheep , rabbit , callipterus cichlid , Angolan giraffe

Categories: Skeleton phene (incl. short stature & teeth)

Links to MONDO diseases: No links.

Mendelian trait/disorder: no

Mode of inheritance: Autosomal recessive

Considered a defect: yes

Key variant known: no

Species-specific description: There have been several isolated reports of dwarfism in pigs. The two reports with the greatest clinical detail are those by Kaman et al. (1991) and Shirota et al. (1995).

Inheritance: Jensen et al. (1984) provided convincing evidence of single-locus autosomal inheritance for one form of porcine dwarfism.

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2012). OMIA:000299-9823: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2018 Chung, J., Zhang, X., Collins, B., Sper, R.B., Gleason, K., Simpson, S., Koh, S., Sommer, J., Flowers, W.L., Petters, R.M., Piedrahita, J.A. :
High mobility group A2 (HMGA2) deficiency in pigs leads to dwarfism, abnormal fetal resource allocation, and cryptorchidism. Proc Natl Acad Sci U S A 115:5420-5425, 2018. Pubmed reference: 29735702. DOI: 10.1073/pnas.1721630115.
1989 Ouhayoun, J.P., Issahakian, S., Patat, J.L., Guillemin, G., Shabana, A.H.M., Sawaf, H., Forest, N. :
Study of a Bone Repairing Process Improvement in Jaws of Dwarf Piglets with Biomaterials - Tricalcium Phosphate, Porous Hydroxyapatite and Natural Coral Hybrid Artificial Organs : Concepts and Development 177:345-350, 1989.
1984 Jensen, P.T., Nielsen, D.H., Jensen, P., Bille, N. :
Hereditary dwarfism in pigs Nordisk Veterinaermedicin 36:32-37, 1984. Pubmed reference: 6728670.
1974 Petrov, A. :
A little known lethal character in pigs [Belgian] Zhivotnovdni Nauki 11:75-79, 1974.
1965 Haring, F., Steinbach, J., Acheven, B. :
Maternal influence on pre- and postnatal development in pigs. I. Studies in crosses of German Large White and dwarf (Vietnamese) pigs Zeitschrift fur Tierzuchtung und Zuchtungsbiologie 82:37-53, 1965.

Edit History

  • Created by Frank Nicholas on 30 Sep 2010
  • Changed by Frank Nicholas on 08 Oct 2011
  • Changed by Frank Nicholas on 09 Dec 2011
  • Changed by Frank Nicholas on 17 Sep 2012