OMIA 000392-9615 : Fragile site in Canis lupus familiaris

In other species: domestic cat , pig , horse , sheep , raccoon dog

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 136540 , 616109 , 136570 , 136580 , 136590 , 601464 , 136620 , 136640 , 601153 , 136660 , 600651 , 601153

Mendelian trait/disorder: unknown

Considered a defect: yes

Cross-species summary: A site on a chromosome that does not stain, at which a break in the chromosome often occurs. In cultured cells, chromosomal breakage at fragile sites can be induced by the addition of caffeine or aphidicolon or bromodeoxyuridine to the culture medium. In humans, fragile sites are sometimes associated with tandem repeats of three nucleotides (triplet microsatellites) which, if the number of repeats increases, can cause inherited disorders. No such examples have yet been documented in domesticated animals.

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
1993 Stone, D.M., Stephens, K.E. :
Animal Model - Bromodeoxyuridine Induces Chromosomal Fragile Sites in the Canine Genome American Journal of Medical Genetics 46:198-202, 1993. Pubmed reference: 8484410. DOI: 10.1002/ajmg.1320460220.
1991 Stone, D.M., Jacky, P.B., Hancock, D.D., Prieur, D.J. :
Animal Model - Chromosomal Fragile Site Expression in Dogs .1. Breed Specific Differences American Journal of Medical Genetics 40:214-222, 1991. Pubmed reference: 1910263. DOI: 10.1002/ajmg.1320400219.
Stone, D.M., Jacky, P.B., Prieur, D.J. :
Animal Model - Chromosomal Fragile Site Expression in Dogs .2. Expression in Boxer Dogs with Mast Cell Tumors American Journal of Medical Genetics 40:223-229, 1991. Pubmed reference: 1910264. DOI: 10.1002/ajmg.1320400220.

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  • Created by Frank Nicholas on 06 Sep 2005