OMIA:000392-9685 : Fragile site in Felis catus (domestic cat)
Categories: Chromosomal disorder
Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 136540 (trait) , 616109 (gene) , 136570 (trait) , 136580 (trait) , 136590 (trait) , 601464 (gene) , 136620 (trait) , 136640 (trait) , 601153 (gene) , 136660 (trait) , 600651 (trait) , 601153 (gene)
Links to MONDO diseases: No links.
Mendelian trait/disorder: unknown
Considered a defect: yes
Cross-species summary: A site on a chromosome that does not stain, at which a break in the chromosome often occurs. In cultured cells, chromosomal breakage at fragile sites can be induced by the addition of caffeine or aphidicolon or bromodeoxyuridine to the culture medium. In humans, fragile sites are sometimes associated with tandem repeats of three nucleotides (triplet microsatellites) which, if the number of repeats increases, can cause inherited disorders. No such examples have yet been documented in domesticated animals.
Have human generated variants been created, e.g. through genetic engineering and gene editing
Cite this entry
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
|1995||Ronne, M. :|
|Localization of fragile sites in the karyotype of felis catus Hereditas 122:279-283, 1995. Pubmed reference: 8537243.|
|1993||Stone, D.M., Stephens, K.E., Doles, J. :|
|Folate-Sensitive and Aphidicolin-Inducible Fragile Sites Are Expressed in the Genome of the Domestic Cat Cancer Genetics and Cytogenetics 65:130-134, 1993. Pubmed reference: 8453598.|
- Created by Frank Nicholas on 06 Sep 2005