OMIA 000392-9796 : Fragile site in Equus caballus

In other species: domestic cat , dog , pig , sheep , raccoon dog

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 136540 , 616109 , 136570 , 136580 , 136590 , 601464 , 136620 , 136640 , 601153 , 136660 , 600651 , 601153

Mendelian trait/disorder: unknown

Considered a defect: yes

Cross-species summary: A site on a chromosome that does not stain, at which a break in the chromosome often occurs. In cultured cells, chromosomal breakage at fragile sites can be induced by the addition of caffeine or aphidicolon or bromodeoxyuridine to the culture medium. In humans, fragile sites are sometimes associated with tandem repeats of three nucleotides (triplet microsatellites) which, if the number of repeats increases, can cause inherited disorders. No such examples have yet been documented in domesticated animals.

Reference


1992 Ronne, M. :
Putative Fragile Sites in the Horse Karyotype Hereditas 117:127-136, 1992. Pubmed reference: 1459856.

Edit History


  • Created by Frank Nicholas on 06 Sep 2005