OMIA:000392-9796 : Fragile site in Equus caballus
Categories: Chromosomal disorder
Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 136540 (trait) , 616109 (gene) , 136570 (trait) , 136580 (trait) , 136590 (trait) , 601464 (gene) , 136620 (trait) , 136640 (trait) , 601153 (gene) , 136660 (trait) , 600651 (trait) , 601153 (gene)
Links to MONDO diseases: No links.
Mendelian trait/disorder: unknown
Considered a defect: yes
Cross-species summary: A site on a chromosome that does not stain, at which a break in the chromosome often occurs. In cultured cells, chromosomal breakage at fragile sites can be induced by the addition of caffeine or aphidicolon or bromodeoxyuridine to the culture medium. In humans, fragile sites are sometimes associated with tandem repeats of three nucleotides (triplet microsatellites) which, if the number of repeats increases, can cause inherited disorders. No such examples have yet been documented in domesticated animals.
Cite this entry
|1992||Ronne, M. :|
|Putative Fragile Sites in the Horse Karyotype Hereditas 117:127-136, 1992. Pubmed reference: 1459856 .|
- Created by Frank Nicholas on 06 Sep 2005