OMIA 000392-34880 : Fragile site in Nyctereutes procyonoides

In other species: dog , domestic cat , horse , pig , sheep

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 136540 , 616109 , 136570 , 136580 , 136590 , 601464 , 136620 , 136640 , 601153 , 136660 , 600651 , 601153

Mendelian trait/disorder: unknown

Considered a defect: yes

Cross-species summary: A site on a chromosome that does not stain, at which a break in the chromosome often occurs. In cultured cells, chromosomal breakage at fragile sites can be induced by the addition of caffeine or aphidicolon or bromodeoxyuridine to the culture medium. In humans, fragile sites are sometimes associated with tandem repeats of three nucleotides (triplet microsatellites) which, if the number of repeats increases, can cause inherited disorders. No such examples have yet been documented in domesticated animals.

Reference


1988 Wurster-Hill, D.H., Ward, O.G., Davis, B.H., Park, J.P., Moyzis, R.K., Meyne, J. :
Fragile sites, telomeric DNA sequences, B chromosomes, and DNA content in raccoon dogs, Nyctereutes procyonoides, with comparative notes on foxes, coyote, wolf, and raccoon. Cytogenet Cell Genet 49:278-81, 1988. Pubmed reference: 3150325.

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  • Created by Frank Nicholas on 06 Sep 2005