OMIA:000392-34880 : Fragile site in Nyctereutes procyonoides (raccoon dog)

In other species: dog , domestic cat , horse , pig , sheep

Categories: Chromosomal disorder

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 136540 (trait) , 616109 (gene) , 136570 (trait) , 136580 (trait) , 136590 (trait) , 601464 (gene) , 136620 (trait) , 136640 (trait) , 601153 (gene) , 136660 (trait) , 600651 (trait) , 601153 (gene)

Mendelian trait/disorder: unknown

Considered a defect: yes

Cross-species summary: A site on a chromosome that does not stain, at which a break in the chromosome often occurs. In cultured cells, chromosomal breakage at fragile sites can be induced by the addition of caffeine or aphidicolon or bromodeoxyuridine to the culture medium. In humans, fragile sites are sometimes associated with tandem repeats of three nucleotides (triplet microsatellites) which, if the number of repeats increases, can cause inherited disorders. No such examples have yet been documented in domesticated animals.

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2005). OMIA:000392-34880: Online Mendelian Inheritance in Animals (OMIA) [dataset].


1988 Wurster-Hill, D.H., Ward, O.G., Davis, B.H., Park, J.P., Moyzis, R.K., Meyne, J. :
Fragile sites, telomeric DNA sequences, B chromosomes, and DNA content in raccoon dogs, Nyctereutes procyonoides, with comparative notes on foxes, coyote, wolf, and raccoon. Cytogenet Cell Genet 49:278-81, 1988. Pubmed reference: 3150325.

Edit History

  • Created by Frank Nicholas on 06 Sep 2005