OMIA:000392-9823 : Fragile site in Sus scrofa
Categories: Chromosomal disorder
Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 136540 (trait) , 616109 (gene) , 136570 (trait) , 136580 (trait) , 136590 (trait) , 601464 (gene) , 136620 (trait) , 136640 (trait) , 601153 (gene) , 136660 (trait) , 600651 (trait) , 601153 (gene)
Links to MONDO diseases: No links.
Mendelian trait/disorder: unknown
Considered a defect: yes
Cross-species summary: A site on a chromosome that does not stain, at which a break in the chromosome often occurs. In cultured cells, chromosomal breakage at fragile sites can be induced by the addition of caffeine or aphidicolon or bromodeoxyuridine to the culture medium. In humans, fragile sites are sometimes associated with tandem repeats of three nucleotides (triplet microsatellites) which, if the number of repeats increases, can cause inherited disorders. No such examples have yet been documented in domesticated animals.
Species-specific description: Some fragile sites in pigs correspond to breakpoints in known reciprocal translocations (Yang and Long, 1993).
Cite this entry
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
|1995||Ronne, M. :|
|Localization of fragile sites in the karyotype of sus scrofa domesticata - present status Hereditas 122:153-162, 1995. Pubmed reference: 7558883 .|
|1993||Riggs, P.K., Kuczek, T., Chrisman, C.L., Bidwell, C.A. :|
|Analysis of Aphidicolin-Induced Chromosome Fragility in the Domestic Pig (Sus-Scrofa) Cytogenetics and Cell Genetics 62:110-116, 1993. Pubmed reference: 8428508 .|
|Yang, M.Y., Long, S.E. :|
|Folate Sensitive Common Fragile Sites in Chromosomes of the Domestic Pig (Sus scrofa) Research in Veterinary Science 55:231-235, 1993. Pubmed reference: 8235092 .|
|1991||Riggs, P.K., Chrisman, C.L. :|
|Identification of Aphidicolin-Induced Fragile Sites in Domestic Pig Chromosomes Genetics Selection Evolution 23:S187-S190, 1991.|
- Created by Frank Nicholas on 06 Sep 2005