OMIA 000478 : Holoprosencephaly

Possible human homologues (MIM numbers): 236100 , 157170 , 142945 , 142946 , 609637 , 605934 , 610828 , 609408 , 610829 , 614226

Cross-species summary: Developmental failure of cleavage of the forebrain (prosencephalon); with a deficit in midline facial development, and with cyclopia (see MIA 000249) in the severe form.

Species in which this phene is found:
domestic cat (Felis catus)
horse (Equus caballus)
pig (Sus scrofa)
sheep (Ovis aries)

Edit History


  • Created by Frank Nicholas on 03 May 2005
  • Changed by Frank Nicholas on 13 Apr 2016