OMIA:000478 : Holoprosencephaly

Categories: Craniofacial phene

Possible human homologues (MIM numbers): 236100 (trait) , 157170 (trait) , 142945 (trait) , 142946 (trait) , 609637 (trait) , 605934 (trait) , 610828 (trait) , 609408 (trait) , 610829 (trait) , 614226 (trait)

Links to MONDO diseases: No links.

Cross-species summary: Developmental failure of cleavage of the forebrain (prosencephalon); with a deficit in midline facial development, and with cyclopia (see OMIA:000249) in the severe form.

Species in which this phene is found:
domestic cat (Felis catus)
horse (Equus caballus)
pig (Sus scrofa)
sheep (Ovis aries)

Edit History


  • Created by Frank Nicholas on 03 May 2005
  • Changed by Frank Nicholas on 13 Apr 2016
  • Changed by Imke Tammen2 on 11 Jul 2021
  • Changed by Imke Tammen2 on 25 Sep 2021
  • Changed by Imke Tammen2 on 09 Feb 2024