OMIA:000478-9823 : Holoprosencephaly in Sus scrofa (pig)

In other species: domestic cat , horse , sheep

Categories: Craniofacial phene

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 236100 (trait) , 157170 (trait) , 142945 (trait) , 142946 (trait) , 609637 (trait) , 605934 (trait) , 610828 (trait) , 609408 (trait) , 610829 (trait) , 614226 (trait)

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: yes

Cross-species summary: Developmental failure of cleavage of the forebrain (prosencephalon); with a deficit in midline facial development, and with cyclopia (see MIA 000249) in the severe form.

Inheritance: There are no data available on inheritance.

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2005). OMIA:000478-9823: Online Mendelian Inheritance in Animals (OMIA) [dataset].


1989 Fisher, K.R.S., Partlow, G.D., Holmes, C.J. :
Anatomical Observations of Holoprosencephaly in Swine Journal of Craniofacial Genetics and Developmental Biology 9:135-146, 1989. Pubmed reference: 2794004.

Edit History

  • Created by Frank Nicholas on 06 Sep 2005