OMIA 000478-9685 : Holoprosencephaly in Felis catus
|Symbol||Description||Species||Chr||Location||OMIA gene details page||Other Links|
|GDF7||growth differentiation factor 7||Felis catus||A3||NC_018725.2 (124737756..124732610)||GDF7||Homologene, Ensembl, NCBI gene|
By default, variants are sorted chronologically by year of publication, to provide a historical perspective. Readers can re-sort on any column by clicking on the column header. Click it again to sort in a descending order. To create a multiple-field sort, hold down Shift while clicking on the second, third etc relevant column headers.
WARNING! Inclusion of a variant in this table does not automatically mean that it should be used for DNA testing. Anyone contemplating the use of any of these variants for DNA testing should examine critically the relevant evidence (especially in breeds other than the breed in which the variant was first described). If it is decided to proceed, the location and orientation of the variant sequence should be checked very carefully.
|Breed(s)||Variant Phenotype||Gene||Allele||Type of Variant||Reference Sequence||Chr.||g. or m.||c. or n.||p.||Verbal Description||EVA ID||Year Published||PubMed ID(s)||Acknowledgements|
|Toyger||Holoprosencephaly||GDF7||deletion, small (<=20)||Felis_catus_9.0||A3||g.127002233_127002239delGCCGCGC||c.221_227delGCCGCGC||p.(Arg74Profs*17)||"a 7 bp deletion in the coding region of GDF7 (c.221_227delGCCGCGC [p.Arg74Profs*17]) at the position A3:127002233 (ENSFCAT00000063603)" (Yu et al., 2020)||2020||32575532|
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
|2020||Lyons, L.A. :|
|Precision medicine in cats-The right biomedical model may not be the mouse! PLoS Genet 16:e1009177, 2020. Pubmed reference: 33290388. DOI: 10.1371/journal.pgen.1009177.|
|Yu, Y., Creighton, E.K., Buckley, R.M., Lyons, L.A. :|
|A Deletion in <i>GDF7</i> is Associated with a Heritable Forebrain Commissural Malformation Concurrent with Ventriculomegaly and Interhemispheric Cysts in Cats. Genes (Basel) 11:, 2020. Pubmed reference: 32575532. DOI: 10.3390/genes11060672.|
|2016||Keating, M.K., Sturges, B.K., Sisó, S., Wisner, E.R., Creighton, E.K., Lyons, L.A. :|
|Characterization of an Inherited Neurologic Syndrome in Toyger Cats with Forebrain Commissural Malformations, Ventriculomegaly and Interhemispheric Cysts. J Vet Intern Med 30:617-26, 2016. Pubmed reference: 26846816. DOI: 10.1111/jvim.13836.|
- Created by Frank Nicholas on 13 Apr 2016
- Changed by Frank Nicholas on 13 Apr 2016
- Changed by Frank Nicholas on 26 Jun 2020