OMIA:000478-9940 : Holoprosencephaly in Ovis aries (sheep)

In other species: domestic cat , horse , pig

Categories: Craniofacial phene

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 236100 (trait) , 157170 (trait) , 142945 (trait) , 142946 (trait) , 609637 (trait) , 605934 (trait) , 610828 (trait) , 609408 (trait) , 610829 (trait) , 614226 (trait)

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: yes

Cross-species summary: Developmental failure of cleavage of the forebrain (prosencephalon); with a deficit in midline facial development, and with cyclopia (see MIA 000249) in the severe form.

Species-specific name: Congenital holoprosencephaly

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2010). OMIA:000478-9940: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2008 Zeiss, CJ., Zarfoss, MK., Johnson, EE., Dubielzig, RR. :
Ocular anomalies and holoprosencephaly in a lamb. Vet Ophthalmol 11:30-3, 2008. Pubmed reference: 18190349 . DOI: 10.1111/j.1463-5224.2007.00597.x.
1987 Roth, IJ., Morrow, CJ., Wilkins, JF., Harper, PA. :
Holoprosencephaly in Border Leicester lambs. Aust Vet J 64:271-3, 1987. Pubmed reference: 3426465 .

Edit History

  • Created by Frank Nicholas on 12 May 2010