OMIA:000478-9796 : Holoprosencephaly in Equus caballus (horse)

In other species: domestic cat , pig , sheep

Categories: Craniofacial phene

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 236100 (trait) , 157170 (trait) , 142945 (trait) , 142946 (trait) , 609637 (trait) , 605934 (trait) , 610828 (trait) , 609408 (trait) , 610829 (trait) , 614226 (trait)

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: yes

Cross-species summary: Developmental failure of cleavage of the forebrain (prosencephalon); with a deficit in midline facial development, and with cyclopia (see OMIA:000249) in the severe form.

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:000478-9796: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2022 Henker, L.C., Lorenzett, M.P., Piva, M.M., Wronski, J.G., de Andrade, D.G.A., Borges, A.S., Driemeier, D., Oliveira-Filho, J.P., Pavarini, S.P. :
Alobar holoprosencephaly in an aborted American Quarter Horse fetus. J Equine Vet Sci 112:103898, 2022. Pubmed reference: 35150851. DOI: 10.1016/j.jevs.2022.103898.
2005 Koch, T., Loretti, A., de Lahunta, A., Kendall, A., Russell, D., Bienzle, D. :
Semilobar holoprosencephaly in a Morgan horse. J Vet Intern Med 19:367-72, 2005. Pubmed reference: 15954555.

Edit History

  • Created by Frank Nicholas on 18 Sep 2005
  • Changed by Imke Tammen2 on 12 Feb 2023