OMIA 000478-9796 : Holoprosencephaly in Equus caballus

In other species: pig , sheep , domestic cat

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 236100 , 157170 , 142945 , 142946 , 609637 , 605934 , 610828 , 609408 , 610829 , 614226

Mendelian trait/disorder: unknown

Considered a defect: yes

Cross-species summary: Developmental failure of cleavage of the forebrain (prosencephalon); with a deficit in midline facial development, and with cyclopia (see MIA 000249) in the severe form.

Reference


2005 Koch, T., Loretti, A., de Lahunta, A., Kendall, A., Russell, D., Bienzle, D. :
Semilobar holoprosencephaly in a Morgan horse. J Vet Intern Med 19:367-72, 2005. Pubmed reference: 15954555.

Edit History


  • Created by Frank Nicholas on 18 Sep 2005