Categories: Immune system phene

Possible human homologues (MIM numbers): 116920 (trait) , 600065 (gene)

Links to relevant human diseases in MONDO:

• MONDO:0007293: leukocyte adhesion deficiency 1

Cross-species summary: Affected animals die because of extreme susceptibility to infections, caused by an inability of white blood cells (leukocytes) to pass from the blood stream into infected tissue. This inability is due to the lack of a membrane glycoprotein called the leukocyte integrin beta-2 subunit or CD18.

Species in which this phene is found:
dog (Canis lupus familiaris)
domestic cat (Felis catus)
taurine cattle (Bos taurus)
indicine cattle (zebu) (Bos indicus)
water buffalo (Bubalus bubalis)