OMIA:000595-9915 : Leukocyte adhesion deficiency, type I in Bos indicus (indicine cattle (zebu))
Categories: Immune system phene
Links to MONDO diseases:
Mendelian trait/disorder: unknown
Considered a defect: yes
Cross-species summary: Affected animals die because of extreme susceptibility to infections, caused by an inability of white blood cells (leukocytes) to pass from the blood stream into infected tissue. This inability is due to the lack of a membrane glycoprotein called the leukocyte integrin beta-2 subunit or CD18.
Species-specific description: Sudhakar et al. (2023) investigated introgression of lethal alleles from taurine cattle into Bos taurus × Bos indicus and Bos indicus cattle in India: “Breed purity analysis confirmed inheritance of Bos taurus genes contributing to the presence of lethal mutant alleles like BLAD, Citrullinemia, HH1, and JH1 in apparently phenotypic Bos indicus animals.”
Have human generated variants been created, e.g. through genetic engineering and gene editing
Cite this entry
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
|2023||Sudhakar, A., Nayee, N., Saha, S., Donthula, S.K., Poojara, H.V., Gohil, T., Patel, A.C., Maurya, B.K. :|
|Role of genetic introgression in introducing mutant alleles in Bos indicus cattle and prevalence of lethal genetic disorders in Bos taurus × Bos indicus and Bos indicus cattle in India. Trop Anim Health Prod 55:399, 2023. Pubmed reference: 37940810. DOI: 10.1007/s11250-023-03798-8.|
|2012||Nasreen, F., Malik, N.A., Qureshi, J.A., Raadsma, H.W., Tammen, I. :|
|Identification of a null allele in genetic tests for bovine leukocyte adhesion deficiency in Pakistani Bos indicus × Bos taurus cattle. Mol Cell Probes 26:259-62, 2012. Pubmed reference: 22374219. DOI: 10.1016/j.mcp.2012.01.004.|
- Created by Imke Tammen2 on 21 Nov 2023
- Changed by Imke Tammen2 on 21 Nov 2023