Categories: Neoplasm

Possible human homologues (MIM numbers): 194070 (trait) , 194071 (trait) , 194072 (trait) , 194080 (trait) , 194090 (trait)

Cross-species summary: A rapidly developing malignant mixed tumour of the kidneys. The Wilms' tumour gene in human and mouse was cloned in the early 1990s. Since its peptide is involved in the development of the urinary-genital tract and the gonads, the gene is of considerable interest in relation to the genetic basis of sexual development. As described in the species summaries, the gene has been amplified by PCR in sheep, cattle and pig, and has been mapped in cattle and sheep. Future studies of this gene should shed interesting light on sexual development, and hence on the occurrence of abnormalities of sexual development in domestic animal species.

Species in which this phene is found:
dog (Canis lupus familiaris)
pig (Sus scrofa)
taurine cattle (Bos taurus)
sheep (Ovis aries)