OMIA:001216-30538 : Coat colour, roan in Vicugna pacos (alpaca)

In other species: dog , horse , pig , taurine cattle , goat , sheep

Categories: Pigmentation phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 184745 (gene) , 611664 (trait)

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal incomplete dominant

Considered a defect: no

Key variant known: yes

Year key variant first reported: 2023

Molecular basis: Shah et al. (2023) "conducted a genome-wide association study (GWAS) by using 13 roan and 14 non-roan alpacas sampled from the USA, Australia, and New Zealand. Regions of genome-wide significance were examined for variants that correlated with the roan phenotype. ... [The authors] identified the candidate SNP-containing region (Super-Scaffold_15:39 742 096–39 887 419) to be a 145 kb copy number variant (CNV) that is likely to be a tandem duplication. All 13 roan alpacas had one or two copies of the roan-associated T allele and all except three non-roans had zero copies."

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
KITLG KIT ligand Vicugna pacos NW_021964178.1 (32000652..32084370) KITLG Homologene, Ensembl , NCBI gene

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:001216-30538: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2023 Shah, I., Gray, N., Groth, D., Brooks, S., Munyard, K. :
A copy number variant near KITLG is associated with the roan pattern in alpacas. Animal Production Science 63:1008-1016, 2023. DOI: 10.1071/AN22463.
2022 Voß, K., Blaj, I., Tetens, J.L., Thaller, G., Becker, D. :
Roan coat color in livestock. Anim Genet 53:549-556, 2022. Pubmed reference: 35811453. DOI: 10.1111/age.13240.

Edit History

  • Created by Imke Tammen2 on 13 Jan 2023
  • Changed by Imke Tammen2 on 27 Jul 2023