OMIA:001216-30538 : Coat colour, roan in Vicugna pacos (alpaca) |
In other species: dog , horse , pig , taurine cattle , goat , sheep
Categories: Pigmentation phene
Links to possible relevant human trait(s) and/or gene(s) in OMIM: 184745 (gene) , 611664 (trait)
Single-gene trait/disorder: yes
Mode of inheritance: Autosomal incomplete dominant
Disease-related: no
Key variant known: yes
Year key variant first reported: 2023
Molecular basis: Shah et al. (2023) "conducted a genome-wide association study (GWAS) by using 13 roan and 14 non-roan alpacas sampled from the USA, Australia, and New Zealand. Regions of genome-wide significance were examined for variants that correlated with the roan phenotype. ... [The authors] identified the candidate SNP-containing region (Super-Scaffold_15:39 742 096–39 887 419) to be a 145 kb copy number variant (CNV) that is likely to be a tandem duplication. All 13 roan alpacas had one or two copies of the roan-associated T allele and all except three non-roans had zero copies."
Associated gene:
Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
---|---|---|---|---|---|---|
KITLG | KIT ligand | Vicugna pacos | NW_021964178.1 (32000652..32084370) | KITLG | Homologene, Ensembl , NCBI gene |
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:001216-30538: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2023 | Shah, I., Gray, N., Groth, D., Brooks, S., Munyard, K. : |
A copy number variant near KITLG is associated with the roan pattern in alpacas. Animal Production Science 63:1008-1016, 2023. DOI: 10.1071/AN22463. | |
2022 | Voß, K., Blaj, I., Tetens, J.L., Thaller, G., Becker, D. : |
Roan coat color in livestock. Anim Genet 53:549-556, 2022. Pubmed reference: 35811453. DOI: 10.1111/age.13240. |
Edit History
- Created by Imke Tammen2 on 13 Jan 2023
- Changed by Imke Tammen2 on 27 Jul 2023