OMIA:002229-9749 : Hypotrichosis, HR-related in Delphinapterus leucas (beluga whale) |
In other species: domestic cat , bottlenosed dolphin , minke whale , pig , sheep , Indo-Pacific finless porpoise , long-beaked common dolphin , Yangtze River dolphin , Omura's baleen whale
Categories: Integument (skin) phene
Links to possible relevant human trait(s) and/or gene(s) in OMIM: 203655 (trait) , 602302 (gene)
Mendelian trait/disorder: yes
Disease-related: no
Key variant known: yes
Year key variant first reported: 2013
Cross-species summary: Also known as Hairless
Molecular basis: Chen et al. (2013) reported evidence that the HR gene in cetaceans, including Delphinapterus leucas, has degenerated into a non-functional pseudogene, which is consistent with the hairlessness of this species.
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| HR | Delphinapterus leucas | NW_022098070.1 (833673..851216) | HR | Homologene, Ensembl , NCBI gene |
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2020). OMIA:002229-9749: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
Reference
| 2013 | Chen, Z., Wang, Z., Xu, S., Zhou, K., Yang, G. : |
| Characterization of hairless (Hr) and FGF5 genes provides insights into the molecular basis of hair loss in cetaceans. BMC Evol Biol 13:34, 2013. Pubmed reference: 23394579. DOI: 10.1186/1471-2148-13-34. |
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- Created by Frank Nicholas on 27 Jan 2020