OMIA:002538-37347 : Alzheimer disease, APP-related in Tupaia belangeri (northern tree shrew) |
In other species: white-tufted-ear marmoset , crab-eating macaque , Rhesus monkey , dog , pig
Categories: Nervous system phene
Links to possible relevant human trait(s) and/or gene(s) in OMIM: 104300 (trait) , 104760 (gene) , 605714 (trait)
Links to relevant human diseases in MONDO:
Single-gene trait/disorder: unknown
Disease-related: yes
Species summary: Yang et al. (2026) "established and characterized a human APP-driven, Aβ-related AD-like tree shrew model following AAV-mediated delivery of triple-mutant human amyloid precursor protein (hAPP-SLA) ... ."
Genetic engineering:
Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing
Contact us
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Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2026). OMIA:002538-37347: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
Reference
| 2026 | Yang, Y., Li, Q., Luo, S., Sun, J., Ouyang, Y. : |
| Establishment and characterization of an Aβ-related Alzheimer's disease-like tree shrew model following CA1-coordinate-directed stereotaxic AAV delivery of human triple-mutant APP. Biology (Basel) 15:1071, 2026. Pubmed reference: 42450618. DOI: 10.3390/biology15131071. |
Edit History
- Created by Imke Tammen on 21 Jul 2026
- Changed by Imke Tammen on 21 Jul 2026