OMIA:002538-9544 : Alzheimer disease, APP-related in Macaca mulatta

In other species: white-tufted-ear marmoset , crab-eating macaque , pig

Categories: Nervous system phene

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 104300 (trait) , 104760 (gene) , 605714 (trait)

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: yes

Species-specific description: Chan et al. (2022): "...two female amyloid-β-(Aβ) precursor protein-transgenic (APPtg) rhesus monkeys were generated by lentiviral transduction of the APP gene ... . ... Overexpression of APP was confirmed in lymphocytes and brain tissue. Upon sacrifice at 10 years of age, one of the monkeys had developed Aβ plaques and cerebral Aβ-amyloid angiopathy in the occipital, parietal, and caudal temporal neocortices."

This phene includes references to studies involving gene edited or genetically modified organisms (GMO).

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
APP amyloid beta (A4) precursor protein Macaca mulatta 3 NC_041756.1 (20490901..20777954) APP Homologene, Ensembl , NCBI gene


2022 Chan, A.W.S., Cho, I.K., Li, C.X., Zhang, X., Patel, S., Rusnak, R., Raper, J., Bachevalier, J., Moran, S.P., Chi, T., Cannon, K.H., Hunter, C.E., Martin, R.C., Xiao, H., Yang, S.H., Gumber, S., Herndon, J.G., Rosen, R.F., Hu, W.T., Lah, J.J., Levey, A.I., Smith, Y., Walker, L.C. :
Cerebral Aβ deposition in an Aβ-precursor protein-transgenic rhesus monkey. Aging Brain 2:100044, 2022. Pubmed reference: 36589695 . DOI: 10.1016/j.nbas.2022.100044.

Edit History

  • Created by Imke Tammen2 on 19 Jan 2023