OMIA:002538-9544 : Alzheimer disease, APP-related in Macaca mulatta |
In other species: white-tufted-ear marmoset , crab-eating macaque , pig
Categories: Nervous system phene
Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 104300 (trait) , 104760 (gene) , 605714 (trait)
Links to MONDO diseases: No links.
Mendelian trait/disorder: unknown
Considered a defect: yes
Species-specific description: Chan et al. (2022): "...two female amyloid-β-(Aβ) precursor protein-transgenic (APPtg) rhesus monkeys were generated by lentiviral transduction of the APP gene ... . ... Overexpression of APP was confirmed in lymphocytes and brain tissue. Upon sacrifice at 10 years of age, one of the monkeys had developed Aβ plaques and cerebral Aβ-amyloid angiopathy in the occipital, parietal, and caudal temporal neocortices."
This phene includes references to studies involving gene edited or genetically modified organisms (GMO).
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| APP | amyloid beta (A4) precursor protein | Macaca mulatta | 3 | NC_041756.1 (20490901..20777954) | APP | Homologene, Ensembl , NCBI gene |
Reference
| 2022 | Chan, A.W.S., Cho, I.K., Li, C.X., Zhang, X., Patel, S., Rusnak, R., Raper, J., Bachevalier, J., Moran, S.P., Chi, T., Cannon, K.H., Hunter, C.E., Martin, R.C., Xiao, H., Yang, S.H., Gumber, S., Herndon, J.G., Rosen, R.F., Hu, W.T., Lah, J.J., Levey, A.I., Smith, Y., Walker, L.C. : |
| Cerebral Aβ deposition in an Aβ-precursor protein-transgenic rhesus monkey. Aging Brain 2:100044, 2022. Pubmed reference: 36589695 . DOI: 10.1016/j.nbas.2022.100044. |
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- Created by Imke Tammen2 on 19 Jan 2023