OMIA:002538-9483 : Alzheimer disease, APP-related in Callithrix jacchus |
In other species: pig , crab-eating macaque , Rhesus monkey
Categories: Nervous system phene
Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 104300 (trait) , 104760 (gene) , 605714 (trait)
Links to MONDO diseases: No links.
Mendelian trait/disorder: unknown
Considered a defect: yes
Species-specific description: Yoshimatsu et al. (2022) "report generation of a non-human primate (NHP), common marmoset model ubiquitously expressing Amyloid-beta precursor protein (APP) transgenes with the Swedish (KM670/671NL) and Indiana (V717F) mutations. ... Although the transgenesis approach alone seemed not sufficient to fully recapitulate AD in NHPs, it may be beneficial for drug development and further disease modeling by combination with other genetically engineered models and disease-inducing approaches."
This study involves genetically modified organisms (GMO).
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| APP | amyloid beta (A4) precursor protein | Callithrix jacchus | 21 | NC_071462.1 (30617470..30336870) | APP | Homologene, Ensembl , NCBI gene |
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2023 | Perez-Cruz, C., Rodriguez-Callejas, J.D. : |
| The common marmoset as a model of neurodegeneration. Trends Neurosci :, 2023. Pubmed reference: 36907677 . DOI: 10.1016/j.tins.2023.02.002. | |
| 2022 | Yoshimatsu, S., Seki, F., Okahara, J., Watanabe, H., Sasaguri, H., Haga, Y., Hata, J.I., Sanosaka, T., Inoue, T., Mineshige, T., Lee, C.Y., Shinohara, H., Kurotaki, Y., Komaki, Y., Kishi, N., Murayama, A.Y., Nagai, Y., Minamimoto, T., Yamamoto, M., Nakajima, M., Zhou, Z., Nemoto, A., Sato, T., Ikeuchi, T., Sahara, N., Morimoto, S., Shiozawa, S., Saido, T.C., Sasaki, E., Okano, H. : |
| Multimodal analyses of a non-human primate model harboring mutant amyloid precursor protein transgenes driven by the human EF1α promoter. Neurosci Res 185:49-61, 2022. Pubmed reference: 36075457 . DOI: 10.1016/j.neures.2022.08.008. |
Edit History
- Created by Imke Tammen2 on 13 Sep 2022
- Changed by Imke Tammen2 on 13 Sep 2022