OMIA 002538-9483 : Alzheimer disease, APP-related in Callithrix jacchus

In other species: crab-eating macaque , pig

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 104300 (trait) , 104760 (gene) , 605714 (trait)

Mendelian trait/disorder: unknown

Considered a defect: yes

Species-specific description: Yoshimatsu et al. (2022) "report generation of a non-human primate (NHP), common marmoset model ubiquitously expressing Amyloid-beta precursor protein (APP) transgenes with the Swedish (KM670/671NL) and Indiana (V717F) mutations. ... Although the transgenesis approach alone seemed not sufficient to fully recapitulate AD in NHPs, it may be beneficial for drug development and further disease modeling by combination with other genetically engineered models and disease-inducing approaches."

This study involves genetically modified organisms (GMO).

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
APP amyloid beta (A4) precursor protein Callithrix jacchus 21 NC_048403.1 (31255596..30974749) APP Homologene, Ensembl, NCBI gene

Reference


2022 Yoshimatsu, S., Seki, F., Okahara, J., Watanabe, H., Sasaguri, H., Haga, Y., Hata, J.I., Sanosaka, T., Inoue, T., Mineshige, T., Lee, C.Y., Shinohara, H., Kurotaki, Y., Komaki, Y., Kishi, N., Murayama, A.Y., Nagai, Y., Minamimoto, T., Yamamoto, M., Nakajima, M., Zhou, Z., Nemoto, A., Sato, T., Ikeuchi, T., Sahara, N., Morimoto, S., Shiozawa, S., Saido, T.C., Sasaki, E., Okano, H. :
Multimodal analyses of a non-human primate model harboring mutant amyloid precursor protein transgenes driven by the human EF1α promoter. Neurosci Res :, 2022. Pubmed reference: 36075457. DOI: 10.1016/j.neures.2022.08.008.

Edit History


  • Created by Imke Tammen2 on 13 Sep 2022
  • Changed by Imke Tammen2 on 13 Sep 2022