OMIA 002538-9541 : Alzheimer disease, APP-related in Macaca fascicularis

In other species: pig

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 104300 (trait) , 104760 (gene) , 605714 (trait)

Mendelian trait/disorder: yes

Considered a defect: yes

Key variant known: yes

Year key variant first reported: 2020

Species-specific description: This animal model of a human disease has been created via transgenic "blastocysts produced by intracytoplasmic sperm injection (ICSI) . . . [being] vitrified and thawed at high efficiency . . . [resulting in] in live births". The resultant animals are, therefore, genetically-modified organisms (GMO).

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
APP amyloid beta precursor protein Macaca fascicularis 3 NC_052257.1 (142113106..141827436) APP Homologene, Ensembl, NCBI gene

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2021 Yang, W., Chen, X., Li, S., Li, X.J. :
Genetically modified large animal models for investigating neurodegenerative diseases. Cell Biosci 11:218, 2021. Pubmed reference: 34933675. DOI: 10.1186/s13578-021-00729-8.
2020 Seita, Y., Morimura, T., Watanabe, N., Iwatani, C., Tsuchiya, H., Nakamura, S., Suzuki, T., Yanagisawa, D., Tsukiyama, T., Nakaya, M., Okamura, E., Muto, M., Ema, M., Nishimura, M., Tooyama, I. :
Generation of transgenic cynomolgus monkeys overexpressing the gene for amyloid-β precursor protein. J Alzheimers Dis 75:45-60, 2020. Pubmed reference: 32250299. DOI: 10.3233/JAD-191081.

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  • Created by Imke Tammen2 on 19 Mar 2022