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OMIA:002538-9541 : Alzheimer disease, APP-related in Macaca fascicularis (crab-eating macaque)

In other species: white-tufted-ear marmoset , Rhesus monkey , dog , pig

Categories: Nervous system phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 104300 (trait) , 104760 (gene) , 605714 (trait)

Links to relevant human diseases in MONDO:

Mendelian trait/disorder: yes

Disease-related: yes

Key variant known: yes

Year key variant first reported: 2020

Species-specific description: This animal model of a human disease has been created via transgenic "blastocysts produced by intracytoplasmic sperm injection (ICSI) . . . [being] vitrified and thawed at high efficiency . . . [resulting in] in live births". The resultant animals are, therefore, genetically-modified organisms (GMO).

Genetic engineering: Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
APP amyloid beta precursor protein Macaca fascicularis 3 NC_088377.1 (20864517..21151647) APP Homologene, Ensembl , NCBI gene

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:002538-9541: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2021 Yang, W., Chen, X., Li, S., Li, X.J. :
Genetically modified large animal models for investigating neurodegenerative diseases. Cell Biosci 11:218, 2021. Pubmed reference: 34933675. DOI: 10.1186/s13578-021-00729-8.
2020 Seita, Y., Morimura, T., Watanabe, N., Iwatani, C., Tsuchiya, H., Nakamura, S., Suzuki, T., Yanagisawa, D., Tsukiyama, T., Nakaya, M., Okamura, E., Muto, M., Ema, M., Nishimura, M., Tooyama, I. :
Generation of transgenic cynomolgus monkeys overexpressing the gene for amyloid-β precursor protein. J Alzheimers Dis 75:45-60, 2020. Pubmed reference: 32250299. DOI: 10.3233/JAD-191081.

Edit History


  • Created by Imke Tammen2 on 19 Mar 2022
  • Changed by Imke Tammen2 on 18 Dec 2023