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OMIA:002630-461220 : Tolerance to batrachotoxin (BTX) in Aleadryas rufinucha (rufous-naped whistler)

In other species: poison dart frogs , regent whistler , hooded pitohui , rusty pitohui , black pitohui , blue-capped ifrita

Categories: Nervous system phene , Muscle phene

Mendelian trait/disorder: unknown

Disease-related: no

Cross-species summary: Batrachotoxin (BTX) is a cardio- and neurotoxic steroidal alkaloid found in beetles, birds and frogs. BTX binds to voltage-gated sodium ion channels (coded for by SCN genes), leading to muscle paralysis and death. Several species of animals with a tolerance or auto-resistance to BTX, acquire BTX in their diet and transport BTX to their skin and/or feathers as a defence mechanism or possible parasite deterrence.

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:002630-461220: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

Reference

2024 Bodawatta, K.H., Hu, H., Schalk, F., Daniel, J.M., Maiah, G., Koane, B., Iova, B., Beemelmanns, C., Poulsen, M., Jønsson, K.A. :
Multiple mutations in the Nav1.4 sodium channel of New Guinean toxic birds provide autoresistance to deadly batrachotoxin. Mol Ecol 33:e16878, 2024. Pubmed reference: 36779590. DOI: 10.1111/mec.16878.

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  • Created by Imke Tammen2 on 17 Feb 2023