OMIA:002771-9615 : Lissencephaly, generic in Canis lupus familiaris (dog)
Categories: Nervous system phene
Links to MONDO diseases: No links.
Mendelian trait/disorder: unknown
Considered a defect: yes
Cross-species summary: Lissencephalic brains (brains with a smooth cerebral cortex) are normal in many species (including some small rodents and small primates). The disease lissencephaly refers to a group of brain conditions in species that normally have gyrencephalic brains, in which the cerebral cortex is smooth due to defective neuronal migration during embryonic development resulting in a reduction or absence of sulci and gyri. Various non-genetic and genetic factors have been reported to cause lissencephaly.
Species-specific description: See also OMIA:001867-9615 : Lissencephaly and cerebellar hypoplasia, RELN-related in Canis lupus familiaris
Have human generated variants been created, e.g. through genetic engineering and gene editing
Australian Kelpie (Dog) (VBO_0200090),
Lhasa Apso (Dog) (VBO_0200824),
Mixed Breed (Dog) (VBO_0200902),
Pekingese (Dog) (VBO_0200994),
Shih Tzu (Dog) (VBO_0201223).
Breeds in which the phene has been documented. For breeds in which a likely causal variant has been documented, see the variant table below
Cite this entry
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
|2020||Rodríguez-Sánchez, D.N., Pinto, G.B.A., Thomé, E.F., Machado, V.M.V., Amorim, R.M. :|
|Lissencephaly in Shih Tzu dogs. Acta Vet Scand 62:32, 2020. Pubmed reference: 32563254. DOI: 10.1186/s13028-020-00528-0.|
|2017||Shimbo, G., Tagawa, M., Oohashi, E., Yanagawa, M., Miyahara, K. :|
|Lissencephaly in a Pekingese. J Vet Med Sci 79:1694-1697, 2017. Pubmed reference: 28819088. DOI: 10.1292/jvms.17-0271.|
|2016||Fraser, A.R., le Chevoir, M.A., Long, S.N. :|
|Lissencephaly in an adult Australian Kelpie. Aust Vet J 94:107-10, 2016. Pubmed reference: 27021891. DOI: 10.1111/avj.12423.|
|2011||Lee, K.I., Lim, C.Y., Kang, B.T., Park, H.M. :|
|Clinical and MRI findings of lissencephaly in a mixed breed dog. J Vet Med Sci 73:1385-8, 2011. Pubmed reference: 21685716.|
|2002||Saito, M., Sharp, N.J., Kortz, G.D., de Lahunta, A., Leventer, R.J., Tokuriki, M., Thrall, D.E. :|
|Magnetic resonance imaging features of lissencephaly in 2 Lhasa Apsos. Vet Radiol Ultrasound 43:331-7, 2002. Pubmed reference: 12174995.|
|1976||Greene, C.E., Vandevelde, M., Braund, K. :|
|Lissencephaly in two Lhasa Apso dogs. J Am Vet Med Assoc 169:405-10, 1976. Pubmed reference: 956022.|
|Zaki, F.A. :|
|Lissencephaly in Lhasa Apso dogs. J Am Vet Med Assoc 169:1165, 1168, 1976. Pubmed reference: 1033927.|
- Created by Imke Tammen2 on 22 Sep 2023
- Changed by Imke Tammen2 on 22 Sep 2023