OMIA:000033-9615 : Alzheimer-like disease, generic in Canis lupus familiaris (dog) |
In other species: white-tufted-ear marmoset , crab-eating macaque , Rhesus monkey , hamadryas baboon , domestic cat , saddleback dolphin , long-finned pilot whale , striped dolphin , bottlenosed dolphin , Cuvier's beaked whale , pig , sheep , domestic guinea pig , degu , white-beaked dolphin , northern tree shrew , short-finned pilot whale , Blainville's beaked whale , green monkey , Indo-pacific bottlenose dolphin , Atlantic spotted dolphin , Chinese tree shrew , black-striped capuchin
Categories: Nervous system phene
Links to possible relevant human trait(s) and/or gene(s) in OMIM: 104300 (trait) , 104310 (trait) , 502500 (trait) , 607822 (trait) , 606889 (trait)
Single-gene trait/disorder: unknown
Disease-related: yes
Cross-species summary: renamed from Alzheimer disease, generic to Alzheimer-like disease, generic [20/07/2023].
Species-specific name: Canine cognitive dysfunction, CCD
Contact us
If you notice anything missing or in need of change, please contact us at: [email protected].
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:000033-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2025 | Alsulami, A., Boland, S.W., McGrath, S., MacLean, E.L., Latimer, C.S., Darvas, M., Moreno, J.A. : |
| Plasma and cerebrospinal fluid biomarkers in aged dogs with cognitive decline. BMC Vet Res 21:617, 2025. Pubmed reference: 41107887. DOI: 10.1186/s12917-025-05027-w. | |
| Dewey, C.W. : | |
| Do hemorrhagic strokes from cerebral amyloid angiopathy represent a clinical entity in senior dogs? J Am Vet Med Assoc :1-3, 2025. Pubmed reference: 41275608. DOI: 10.2460/javma.25.09.0574. | |
| Harrison, B.R., Partida-Aguilar, M., Marye, A., Djukovic, D., Kauffman, M., Dunbar, M.D., Mariner, B.L., McCoy, B.M., Algavi, Y.M., Muller, E., Baum, S., Bamberger, T., Raftery, D., Creevy, K.E. : | |
| Protein catabolites as blood-based biomarkers of aging physiology: Findings from the dog aging project. Aging Cell 24:e70226, 2025. Pubmed reference: 41121965. DOI: 10.1111/acel.70226. | |
| Henry, J., Ukai, M., Antonakakis, M., Zhou, T., Moreno, J.A., Burzynska, A.Z., McGrath, S. : | |
| Diffusion tensor imaging analysis of aged dogs with and without canine cognitive dysfunction. BMC Vet Res 21:550, 2025. Pubmed reference: 41039478. DOI: 10.1186/s12917-025-04973-9. | |
| Kayano, M. : | |
| Exploring efficient and effective mammalian models for Alzheimer's disease. Front Aging Neurosci 17:1652754, 2025. Pubmed reference: 40893124. DOI: 10.3389/fnagi.2025.1652754. | |
| McGrath, S., Hull, E., Dunbar, M.D., Prescott, J., Keyser, A.J., MacLean, E., Darvas, M., Latimer, C., Moreno, J., MacCoss, M.J., Kauffman, M., Litwin, P., Castelhano, M., Kaeberlein, M., Keene, C.D. : | |
| The companion dog as a translational model for Alzheimer's disease: Development of a longitudinal research platform and post mortem protocols. Alzheimers Dement 21:e70630, 2025. Pubmed reference: 40995864. DOI: 10.1002/alz.70630. | |
| Merbl, Y., Mondrus, E., Hanael, E., Shamir, M.H. : | |
| Blood-brain barrier permeability changes in dogs with suspected canine cognitive dysfunction using magnetic resonance imaging subtraction enhancement analysis. Front Vet Sci 12:1572286, 2025. Pubmed reference: 40433457. DOI: 10.3389/fvets.2025.1572286. | |
| Quadalti, C. : | |
| One health, two species: Linking domestication to cognitive aging in dogs and humans. Animals (Basel) 15:2851, 2025. Pubmed reference: 41096446. DOI: 10.3390/ani15192851. | |
| Simon, K.E., Gruen, M.E., Olby, N.J. : | |
| Current practices for diagnosis and management of Canine Cognitive Dysfunction Syndrome in the United States. Front Vet Sci 12:1685430, 2025. Pubmed reference: 41234399. DOI: 10.3389/fvets.2025.1685430. | |
| Vitturini, C., Cerquetella, M., Spaterna, A., Bazzano, M., Marchegiani, A. : | |
| Diagnosis of canine cognitive dysfunction syndrome: A narrative review. Vet Sci 12:781, 2025. Pubmed reference: 40872731. DOI: 10.3390/vetsci12080781. | |
| Yoon, J.W., Nam, C.S., Lee, K.S., Dan, T.J., Jeon, H.J., Kang, M.A., Park, H.M. : | |
| Evaluation of blood-based diagnostic biomarkers for canine cognitive dysfunction syndrome. Animals (Basel) 15:1974, 2025. Pubmed reference: 40646873. DOI: 10.3390/ani15131974. | |
| 2024 | Kim, C.Y., Kim, J., Yoon, S., Yi, I.J., Lee, H., Seo, S., Kim, D.W., Ko, S., Kim, S.A., Kwon, C., Yi, S.S. : |
| Advancing the early detection of canine cognitive dysfunction syndrome with machine learning-enhanced blood-based biomarkers. Front Vet Sci 11:1390296, 2024. Pubmed reference: 39170638. DOI: 10.3389/fvets.2024.1390296. | |
| Mariner, B.L., McCoy, B.M., Greenier, A., Brassington, L., Silkas, E., Adjangba, C., Marye, A., Harrison, B.R., Bamberger, T., Algavi, Y., Muller, E., Harris, A., Rout, E. : | |
| DNA methylation of transposons pattern aging differences across a diverse cohort of dogs from the Dog Aging Project. bioRxiv , 2024. Pubmed reference: 39416178. DOI: 10.1101/2024.10.08.617286. | |
| Sordo, L., Ubele, M.F., Boaz, K.A., Mefford, J.L., Jones, E.D., McCarty, K.L., van Rooyen, H.Y., Smiley, J., Bembenek Bailey, S.A., Perpich, J.A., Meacham, B., Powell, D.K., Bresch, F., Crump, J.W., Phelan, M.J., Noche, J.A., Stark, C.E., Puskás, L.G., Norris, C.M., Head, E. : | |
| Calcineurin/NFAT inhibitors maintain cognition in a preclinical prevention study in an aging canine model of Alzheimer disease. Neurobiol Aging 146:S0197-4580(24)00187-8:1-14, 2024. Pubmed reference: 39547056. DOI: 10.1016/j.neurobiolaging.2024.11.003. | |
| Turcsán, B., Kubinyi, E. : | |
| Differential behavioral aging trajectories according to body size, expected lifespan, and head shape in dogs. Geroscience 46:1731-1754, 2024. Pubmed reference: 37740140. DOI: 10.1007/s11357-023-00945-9. | |
| 2023 | de Sousa, A.A., Rigby Dames, B.A., Graff, E.C., Mohamedelhassan, R., Vassilopoulos, T., Charvet, C.J. : |
| Going beyond established model systems of Alzheimer's disease: companion animals provide novel insights into the neurobiology of aging. Commun Biol 6:655, 2023. Pubmed reference: 37344566. DOI: 10.1038/s42003-023-05034-3. | |
| Dewey, C.W., Rishniw, M., Sakovitch, K., Hollenbeck, J. : | |
| Oral administration of an integrative supplement (CogniCaps<sup>®</sup>) improves cognitive scores in aging dogs with canine cognitive dysfunction for at least two months: An open-label investigation in 10 dogs. Open Vet J 13:188-192, 2023. Pubmed reference: 37073246. DOI: 10.5455/OVJ.2023.v13.i2.6. | |
| Ehrenzweig, J., Hunter, R.P. : | |
| Canine cognitive decline and Alzheimer disease: clinical insights to solve a shared one-health problem. J Am Vet Med Assoc 261:1597-1604, 2023. Pubmed reference: 37758186. DOI: 10.2460/javma.23.02.0095. | |
| Hines, A.D., McGrath, S., Latham, A.S., Kusick, B., Mulligan, L., Richards, M.L., Moreno, J.A. : | |
| Activated gliosis, accumulation of amyloid β, and hyperphosphorylation of tau in aging canines with and without cognitive decline. Front Aging Neurosci 15:1128521, 2023. Pubmed reference: 37304080. DOI: 10.3389/fnagi.2023.1128521. | |
| Hunter, R.P., Ehrenzweig, J., Hainsworth, A., Crawford, A., Dagan, A., Sage, J., Araujo, J. : | |
| One-health approach to canine cognitive decline: Dogs Overcoming Geriatric Memory and Aging Initiative for early detection of cognitive decline. Am J Vet Res 84, 2023. Pubmed reference: 37739391. DOI: 10.2460/ajvr.23.02.0032. | |
| Kutzsche, J., Schemmert, S., Bujnicki, T., Zafiu, C., Halbgebauer, S., Kraemer-Schulien, V., Pils, M., Blömeke, L., Post, J., Kulawik, A., Jürgens, D., Rossberg, W.M., Hümpel, M., Bannach, O., Otto, M., Araujo, J.A., Willuweit, A., Willbold, D. : | |
| Oral treatment with the all-d-peptide RD2 enhances cognition in aged beagle dogs - A model of sporadic Alzheimer's disease. Heliyon 9:e18443, 2023. Pubmed reference: 37609390. DOI: 10.1016/j.heliyon.2023.e18443. | |
| Mondino, A., Khan, M., Case, B., Fefer, G., Panek, W.K., Gruen, M.E., Olby, N.J. : | |
| Winning the race with aging: age-related changes in gait speed and its association with cognitive performance in dogs. Front Vet Sci 10:1150590, 2023. Pubmed reference: 37396989. DOI: 10.3389/fvets.2023.1150590. | |
| Mondino, A., Catanzariti, M., Mateos, D.M., Khan, M., Ludwig, C., Kis, A., Gruen, M.E., Olby, N.J. : | |
| Sleep and cognition in aging dogs. A polysomnographic study. Front Vet Sci 10:1151266, 2023. Pubmed reference: 37187924. DOI: 10.3389/fvets.2023.1151266. | |
| Prévot, V., Duittoz, A. : | |
| A role for GnRH in olfaction and cognition: Implications for veterinary medicine. Reprod Domest Anim 58 Suppl 2:109-124, 2023. Pubmed reference: 37329313. DOI: 10.1111/rda.14411. | |
| Templeton, G.B., Fefer, G., Case, B.C., Roach, J., Azcarate-Peril, M.A., Gruen, M.E., Callahan, B.J., Olby, N.J. : | |
| Longitudinal analysis of canine oral microbiome using whole genome sequencing in aging companion dogs. Animals (Basel) 13:3846, 2023. Pubmed reference: 38136883. DOI: 10.3390/ani13243846. | |
| Wrightson, R., Albertini, M., Pirrone, F., McPeake, K., Piotti, P. : | |
| The relationship between signs of medical conditions and cognitive decline in senior dogs. Animals (Basel) 13:2203, 2023. Pubmed reference: 37443999. DOI: 10.3390/ani13132203. | |
| Wu, C.H., Pan, X.S., Su, L.Y., Yang, S.Y. : | |
| Plasma neurofilament light chains as blood-based biomarkers for early diagnosis of canine cognitive dysfunction syndrome. Int J Mol Sci 24:13771, 2023. Pubmed reference: 37762074. DOI: 10.3390/ijms241813771. | |
| 2020 | Story, B.D., Miller, M.E., Bradbury, A.M., Million, E.D., Duan, D., Taghian, T., Faissler, D., Fernau, D., Beecy, S.J., Gray-Edwards, H.L. : |
| Canine models of inherited musculoskeletal and neurodegenerative diseases. Front Vet Sci 7:80, 2020. Pubmed reference: 32219101. DOI: 10.3389/fvets.2020.00080. | |
| 2012 | Bosch, M.N., Pugliese, M., Gimeno-Bayón, J., Rodríguez, M.J., Mahy, N. : |
| Dogs with cognitive dysfunction syndrome: a natural model of Alzheimer's disease. Curr Alzheimer Res 9:298-314, 2012. Pubmed reference: 21875411. | |
| 2011 | González-Martínez, Á., Rosado, B., Pesini, P., Suárez, M.L., Santamarina, G., García-Belenguer, S., Villegas, A., Monleón, I., Sarasa, M. : |
| Plasma β-amyloid peptides in canine aging and cognitive dysfunction as a model of Alzheimer's disease. Exp Gerontol 46:590-6, 2011. Pubmed reference: 21377518. DOI: 10.1016/j.exger.2011.02.013. | |
| 2009 | Sarasa, M., Pesini, P. : |
| Natural non-trasgenic animal models for research in Alzheimer's disease. Curr Alzheimer Res 6:171-8, 2009. Pubmed reference: 19355852. | |
| 2008 | Cotman, CW., Head, E. : |
| The canine (dog) model of human aging and disease: dietary, environmental and immunotherapy approaches. J Alzheimers Dis 15:685-707, 2008. Pubmed reference: 19096165. | |
| 2006 | Rofina, JE., van Ederen, AM., Toussaint, MJ., Secreve, M., van der Spek, A., van der Meer, I., Van Eerdenburg, FJ., Gruys, E. : |
| Cognitive disturbances in old dogs suffering from the canine counterpart of Alzheimer's disease. Brain Res 1069:216-26, 2006. Pubmed reference: 16423332. DOI: 10.1016/j.brainres.2005.11.021. | |
| 2003 | Rofina, J., van Andel, I., van Ederen, AM., Papaioannou, N., Yamaguchi, H., Gruys, E. : |
| Canine counterpart of senile dementia of the Alzheimer type: amyloid plaques near capillaries but lack of spatial relationship with activated microglia and macrophages. Amyloid 10:86-96, 2003. Pubmed reference: 12964416. | |
| 2001 | Head, E. : |
| Brain aging in dogs: parallels with human brain aging and Alzheimer's disease. Vet Ther 2:247-60, 2001. Pubmed reference: 19746668. | |
| 1997 | Lim, G.P., Russell, M.J., Cullen, M.J., Tokes, Z.A. : |
| Matrix metalloproteinases in dog brains exhibiting alzheimer-like characteristics Journal of Neurochemistry 68:1606-1611, 1997. Pubmed reference: 9084432. | |
| 1993 | Cummings, B.J., Su, J.H., Cotman, C.W., White, R., Russell, M.J. : |
| beta-amyloid accumulation in aged canine brain - A model of early plaque formation in Alzheimers disease. Neurobiol Aging 14:547-60, 1993. Pubmed reference: 8295657. DOI: 10.1016/0197-4580(93)90038-d. |
Edit History
- Created by Frank Nicholas on 06 Sep 2005
- Changed by Imke Tammen2 on 21 Apr 2023