OMIA 000033-9940 : Alzheimer disease, generic in Ovis aries

In other species: crab-eating macaque , dog , domestic cat , pig , degu

Category: Nervous system phene

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 104300 (trait) , 104310 (trait) , 502500 (trait) , 607822 (trait) , 606889 (trait)

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: yes

Species-specific description: Davies et al. (2022) "show that sheep exhibit naturally occurring β-amyloid and tau pathologies, that reflect those that occur in the early stages of Alzheimer's disease."


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year. > >
2022 Banstola, A., Reynolds, J.N.J. :
The sheep as a large animal model for the investigation and treatment of human disorders. Biology (Basel) 11:1251, 2022. Pubmed reference: 36138730. DOI: 10.3390/biology11091251.
Davies, E.S., Morphew, R.M., Cutress, D., Morton, A.J., McBride, S. :
Characterization of microtubule-associated protein tau isoforms and Alzheimer's disease-like pathology in normal sheep (Ovis aries): relevance to their potential as a model of Alzheimer's disease. Cell Mol Life Sci 79:560, 2022. Pubmed reference: 36269420. DOI: 10.1007/s00018-022-04572-z.

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  • Created by Imke Tammen2 on 10 Nov 2022