OMIA 000033-9940 : Alzheimer disease, generic in Ovis aries
Category: Nervous system phene
Links to MONDO diseases: No links.
Mendelian trait/disorder: unknown
Considered a defect: yes
Species-specific description: Davies et al. (2022) "show that sheep exhibit naturally occurring β-amyloid and tau pathologies, that reflect those that occur in the early stages of Alzheimer's disease."
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
|2022||Banstola, A., Reynolds, J.N.J. :>|
|The sheep as a large animal model for the investigation and treatment of human disorders. Biology (Basel) 11:1251, 2022. Pubmed reference: 36138730. DOI: 10.3390/biology11091251.|
|Davies, E.S., Morphew, R.M., Cutress, D., Morton, A.J., McBride, S. :>|
|Characterization of microtubule-associated protein tau isoforms and Alzheimer's disease-like pathology in normal sheep (Ovis aries): relevance to their potential as a model of Alzheimer's disease. Cell Mol Life Sci 79:560, 2022. Pubmed reference: 36269420. DOI: 10.1007/s00018-022-04572-z.|
- Created by Imke Tammen2 on 10 Nov 2022