OMIA 000033-9541 : Alzheimer disease in Macaca fascicularis |
In other species:
dog
,
degu
Possibly relevant human trait(s) and/or gene(s)s (MIM numbers):
104300
,
104310
,
104311
,
104760
,
163890
,
502500
,
600759
Mendelian trait/disorder:
yes
Considered a defect:
yes
Key variant known:
no
Species-specific description:
This animal model of a human disease has been created via transgenic "blastocysts produced by intracytoplasmic sperm injection (ICSI) . . . [being] vitrified and thawed at high efficiency . . . [resulting in] in live births". The resultant animals are, therefore, genetically-modified organisms (GMO).
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| APP | amyloid beta precursor protein | Macaca fascicularis | 3 | NC_022274.1 (20805544..21093823) | APP | Homologene, Ensembl, NCBI gene |
Reference
| 2020 | Seita, Y., Morimura, T., Watanabe, N., Iwatani, C., Tsuchiya, H., Nakamura, S., Suzuki, T., Yanagisawa, D., Tsukiyama, T., Nakaya, M., Okamura, E., Muto, M., Ema, M., Nishimura, M., Tooyama, I. : | |
| Generation of Transgenic Cynomolgus Monkeys Overexpressing the Gene for Amyloid-β Precursor Protein. J Alzheimers Dis :, 2020. Pubmed reference: 32250299. DOI: 10.3233/JAD-191081. |
Edit History
- Created by Frank Nicholas on 08 Apr 2020
- Changed by Frank Nicholas on 08 Apr 2020