OMIA 000595 : Leukocyte adhesion deficiency, type I

Possible human homologues (MIM numbers): 116920 (trait) , 600065 (gene)

Cross-species summary: Affected animals die because of extreme susceptibility to infections, caused by an inability of white blood cells (leukocytes) to pass from the blood stream into infected tissue. This inability is due to the lack of a membrane glycoprotein called the leukocyte integrin beta-2 subunit or CD18.

Species in which this phene is found:
dog (Canis lupus familiaris)
domestic cat (Felis catus)
cattle (Bos taurus)
water buffalo (Bubalus bubalis)

Edit History


  • Created by Frank Nicholas on 03 May 2005
  • Changed by Frank Nicholas on 26 Sep 2011
  • Changed by Imke Tammen2 on 19 Aug 2021
  • Changed by Imke Tammen2 on 25 Sep 2021