OMIA:000683-1234273 : Muscular hypertrophy (double muscling) in Tachysurus fulvidraco (yellow catfish)
Categories: Muscle phene
Links to MONDO diseases:
Mendelian trait/disorder: yes
Considered a defect: yes
Key variant known: no
Cross-species summary: Abnormal increase in muscular tissue caused entirely by enlargement of existing cells (in contrast to muscular hyperplasia, in which the abnormal increase in muscular tissue is due to the formation and growth of new, normal muscle cells)
Species-specific description: Zhang et al. (2020, 2023) investigated mstna and mstnb gene knockout in yellow catfish, as variants in the myostatin gene (MSTN) gene are known to cause muscular hypertrophy in several animal species. Knock out of mstna in yellow catfish increased muscle mass (Zhang et al. 2020) but knockout of mstnb "reduced the body size and growth performance ... . It was found that mstnb gene knockdown resulted in a reduction in the number of vertebrae, the length, and the intervertebral distance ... . Further, histological comparison of the same sites in the mstn mutant and wild groups ... revealed that the number and density of osteocytes were greater in mstnb knockout ... . [The] results demonstrated that when using genome editing technology to breed new lines, the effects of knockout need to be analyzed comprehensively and may have some unexpected effects due to insufficient study of the function of certain genes."
This phene includes references to studies involving gene edited or genetically modified organisms (GMO).
Have human generated variants been created, e.g. through genetic engineering and gene editing
Cite this entry
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
|2023||Zhang, X., Wang, F., Ou, M., Liu, H., Luo, Q., Fei, S., Zhao, J., Chen, K., Zhao, Q., Li, K. :|
|Effects of myostatin b knockout on offspring body length and skeleton in yellow catfish (Pelteobagrus fulvidraco). Biology (Basel) 12, 2023. Pubmed reference: 37887041. DOI: 10.3390/biology12101331.|
|2020||Zhang, X., Wang, F., Dong, Z., Dong, X., Chi, J., Chen, H., Zhao, Q., Li, K. :|
|A new strain of yellow catfish carrying genome edited myostatin alleles exhibits double muscling phenotype with hyperplasia. Aquaculture 523:735187, 2020. DOI: 10.1016/j.aquaculture.2020.735187.|
|2014||Dong, Z., Ge, J., Xu, Z., Dong, X., Cao, S., Pan, J., Zhao, Q. :|
|Generation of myostatin B knockout yellow catfish (Tachysurus fulvidraco) using transcription activator-like effector nucleases. Zebrafish 11:265-74, 2014. Pubmed reference: 24813227. DOI: 10.1089/zeb.2014.0974.|
|2011||Dong, Z., Ge, J., Li, K., Xu, Z., Liang, D., Li, J., Li, J., Jia, W., Li, Y., Dong, X., Cao, S., Wang, X., Pan, J., Zhao, Q. :|
|Heritable targeted inactivation of myostatin gene in yellow catfish (Pelteobagrus fulvidraco) using engineered zinc finger nucleases. PLoS One 6:e28897, 2011. Pubmed reference: 22194943. DOI: 10.1371/journal.pone.0028897.|
- Created by Imke Tammen2 on 05 Nov 2023
- Changed by Imke Tammen2 on 05 Nov 2023