OMIA:000683-1234273 : Muscular hypertrophy (double muscling) in Tachysurus fulvidraco (yellow catfish)

In other species: Japanese flounder , rock pigeon , chicken , dog , pig , taurine cattle , goat , sheep , rabbit , water buffalo , Japanese quail

Categories: Muscle phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 601788 (gene) , 614160 (trait)

Links to relevant human diseases in MONDO:

Mendelian trait/disorder: yes

Considered a defect: yes

Key variant known: no

Cross-species summary: Abnormal increase in muscular tissue caused entirely by enlargement of existing cells (in contrast to muscular hyperplasia, in which the abnormal increase in muscular tissue is due to the formation and growth of new, normal muscle cells)

Species-specific description: Zhang et al. (2020, 2023) investigated mstna and mstnb gene knockout in yellow catfish, as variants in the myostatin gene (MSTN) gene are known to cause muscular hypertrophy in several animal species. Knock out of mstna in yellow catfish increased muscle mass (Zhang et al. 2020) but knockout of mstnb "reduced the body size and growth performance ... . It was found that mstnb gene knockdown resulted in a reduction in the number of vertebrae, the length, and the intervertebral distance ... . Further, histological comparison of the same sites in the mstn mutant and wild groups ... revealed that the number and density of osteocytes were greater in mstnb knockout ... . [The] results demonstrated that when using genome editing technology to breed new lines, the effects of knockout need to be analyzed comprehensively and may have some unexpected effects due to insufficient study of the function of certain genes." This phene includes references to studies involving gene edited or genetically modified organisms (GMO).

Genetic engineering: Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:000683-1234273: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2023 Zhang, X., Wang, F., Ou, M., Liu, H., Luo, Q., Fei, S., Zhao, J., Chen, K., Zhao, Q., Li, K. :
Effects of myostatin b knockout on offspring body length and skeleton in yellow catfish (Pelteobagrus fulvidraco). Biology (Basel) 12:1331, 2023. Pubmed reference: 37887041. DOI: 10.3390/biology12101331.
2020 Zhang, X., Wang, F., Dong, Z., Dong, X., Chi, J., Chen, H., Zhao, Q., Li, K. :
A new strain of yellow catfish carrying genome edited myostatin alleles exhibits double muscling phenotype with hyperplasia. Aquaculture 523:735187, 2020. DOI: 10.1016/j.aquaculture.2020.735187.
2014 Dong, Z., Ge, J., Xu, Z., Dong, X., Cao, S., Pan, J., Zhao, Q. :
Generation of myostatin B knockout yellow catfish (Tachysurus fulvidraco) using transcription activator-like effector nucleases. Zebrafish 11:265-74, 2014. Pubmed reference: 24813227. DOI: 10.1089/zeb.2014.0974.
2011 Dong, Z., Ge, J., Li, K., Xu, Z., Liang, D., Li, J., Li, J., Jia, W., Li, Y., Dong, X., Cao, S., Wang, X., Pan, J., Zhao, Q. :
Heritable targeted inactivation of myostatin gene in yellow catfish (Pelteobagrus fulvidraco) using engineered zinc finger nucleases. PLoS One 6:e28897, 2011. Pubmed reference: 22194943. DOI: 10.1371/journal.pone.0028897.

Edit History

  • Created by Imke Tammen2 on 05 Nov 2023
  • Changed by Imke Tammen2 on 05 Nov 2023
  • Changed by Imke Tammen2 on 12 Dec 2023