OMIA 000683-9986 : Muscular hypertrophy (double muscling) in Oryctolagus cuniculus
Category: Muscle phene
Links to MONDO diseases: No links.
Mendelian trait/disorder: yes
Considered a defect: unknown
Key variant known: no
Cross-species summary: Abnormal increase in muscular tissue caused entirely by enlargement of existing cells (in contrast to muscular hyperplasia, in which the abnormal increase in muscular tissue is due to the formation and growth of new, normal muscle cells)
Species-specific description: The affected rabbits described by Liu et al. (2018) are generated by genome editing and are considered genetically-modified organisms (GMO).
|Symbol||Description||Species||Chr||Location||OMIA gene details page||Other Links|
|MSTN||myostatin||Oryctolagus cuniculus||7||NC_067380.1 (43163543..43168454)||MSTN||Homologene, Ensembl, NCBI gene|
|2018||Liu, Z., Chen, M., Chen, S., Deng, J., Song, Y., Lai, L., Li, Z. :>|
|Highly efficient RNA-guided base editing in rabbit. Nat Commun 9:2717, 2018. Pubmed reference: 30006570. DOI: 10.1038/s41467-018-05232-2.|
- Created by Imke Tammen2 on 26 Jan 2021
- Changed by Imke Tammen2 on 26 Jan 2021
- Changed by Imke Tammen2 on 28 Jan 2021