OMIA:000683-9986 : Muscular hypertrophy (double muscling) in Oryctolagus cuniculus |
In other species: taurine cattle , pig , dog , chicken , goat , Japanese quail , sheep , water buffalo
Categories: Muscle phene
Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 601788 (gene) , 614160 (trait)
Links to MONDO diseases:
Mendelian trait/disorder: yes
Considered a defect: unknown
Key variant known: no
Cross-species summary: Abnormal increase in muscular tissue caused entirely by enlargement of existing cells (in contrast to muscular hyperplasia, in which the abnormal increase in muscular tissue is due to the formation and growth of new, normal muscle cells)
Species-specific description: The affected rabbits described by Liu et al. (2018) are generated by genome editing and are considered genetically-modified organisms (GMO).
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| MSTN | myostatin | Oryctolagus cuniculus | 7 | NC_067380.1 (43163543..43168454) | MSTN | Homologene, Ensembl , NCBI gene |
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:000683-9986: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2022 | Zheng, Y., Zhang, Y., Wu, L., Riaz, H., Li, Z., Shi, D., Rehman, S.U., Liu, Q., Cui, K. : |
| Generation of heritable prominent double muscle buttock rabbits via novel site editing of myostatin gene using CRISPR/Cas9 system. Front Vet Sci 9:842074, 2022. Pubmed reference: 35669173 . DOI: 10.3389/fvets.2022.842074. | |
| 2018 | Liu, Z., Chen, M., Chen, S., Deng, J., Song, Y., Lai, L., Li, Z. : |
| Highly efficient RNA-guided base editing in rabbit. Nat Commun 9:2717, 2018. Pubmed reference: 30006570 . DOI: 10.1038/s41467-018-05232-2. |
Edit History
- Created by Imke Tammen2 on 26 Jan 2021
- Changed by Imke Tammen2 on 26 Jan 2021
- Changed by Imke Tammen2 on 28 Jan 2021
- Changed by Imke Tammen2 on 13 Jan 2023