OMIA 000683-9031 : Muscular hypertrophy (double muscling) in Gallus gallus

In other species: cattle , pig , dog , rabbit , goat , Japanese quail

Category: Muscle phene

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 601788 (gene) , 614160 (trait)

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: no

Cross-species summary: Abnormal increase in muscular tissue caused entirely by enlargement of existing cells (in contrast to muscular hyperplasia, in which the abnormal increase in muscular tissue is due to the formation and growth of new, normal muscle cells)

Species-specific description: This is a genetically-modified organism; GMO

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
MSTN myostatin Gallus gallus 7 NC_052538.1 (305390..312076) MSTN Homologene, Ensembl, NCBI gene

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year. > > > > >
2021 Petry, B., Moreira, G.C.M., Copola, A.G.L., de Souza, M.M., da Veiga, F.C., Jorge, E.C., de Oliveira Peixoto, J., Ledur, M.C., Koltes, J.E., Coutinho, L.L. :
SAP30 gene is a probable regulator of muscle hypertrophy in chickens. Front Genet 12:709937, 2021. Pubmed reference: 34646299. DOI: 10.3389/fgene.2021.709937.
2020 Kim, G.D., Lee, J.H., Song, S., Kim, S.W., Han, J.S., Shin, S.P., Park, B.C., Park, T.S. :
Generation of myostatin-knockout chickens mediated by D10A-Cas9 nickase. FASEB J 34:5688-5696, 2020. Pubmed reference: 32100378. DOI: 10.1096/fj.201903035R.
2018 Aiello, D., Patel, K., Lasagna, E. :
The myostatin gene: an overview of mechanisms of action and its relevance to livestock animals. Anim Genet 49:505-19, 2018. Pubmed reference: 30125951. DOI: 10.1111/age.12696.
2016 Bhattacharya, T.K., Shukla, R., Chatterjee, R.N., Dushyanth, K. :
Knock down of the myostatin gene by RNA interference increased body weight in chicken. J Biotechnol :, 2016. Pubmed reference: 27845166. DOI: 10.1016/j.jbiotec.2016.11.012.
2002 Mott, I., Ivarie, R. :
Expression of myostatin is not altered in lines of poultry exhibiting myofiber hyper- and hypoplasia. Poult Sci 81:799-804, 2002. Pubmed reference: 12079046.

Edit History


  • Created by Frank Nicholas on 18 Nov 2016
  • Changed by Imke Tammen2 on 30 Aug 2021
  • Changed by Imke Tammen2 on 19 Oct 2021