OMIA:000683-9031 : Muscular hypertrophy (double muscling) in Gallus gallus |
In other species: cattle , pig , dog , rabbit , goat , Japanese quail , sheep , water buffalo
Categories: Muscle phene
Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 601788 (gene) , 614160 (trait)
Links to MONDO diseases:
Mendelian trait/disorder: unknown
Considered a defect: no
Cross-species summary: Abnormal increase in muscular tissue caused entirely by enlargement of existing cells (in contrast to muscular hyperplasia, in which the abnormal increase in muscular tissue is due to the formation and growth of new, normal muscle cells)
Species-specific description: This is a genetically-modified organism; GMO
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| MSTN | myostatin | Gallus gallus | 7 | NC_052538.1 (305390..312076) | MSTN | Homologene, Ensembl , NCBI gene |
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2021 | Petry, B., Moreira, G.C.M., Copola, A.G.L., de Souza, M.M., da Veiga, F.C., Jorge, E.C., de Oliveira Peixoto, J., Ledur, M.C., Koltes, J.E., Coutinho, L.L. : |
| SAP30 gene is a probable regulator of muscle hypertrophy in chickens. Front Genet 12:709937, 2021. Pubmed reference: 34646299 . DOI: 10.3389/fgene.2021.709937. | |
| 2020 | Kim, G.D., Lee, J.H., Song, S., Kim, S.W., Han, J.S., Shin, S.P., Park, B.C., Park, T.S. : |
| Generation of myostatin-knockout chickens mediated by D10A-Cas9 nickase. FASEB J 34:5688-5696, 2020. Pubmed reference: 32100378 . DOI: 10.1096/fj.201903035R. | |
| 2018 | Aiello, D., Patel, K., Lasagna, E. : |
| The myostatin gene: an overview of mechanisms of action and its relevance to livestock animals. Anim Genet 49:505-19, 2018. Pubmed reference: 30125951 . DOI: 10.1111/age.12696. | |
| 2016 | Bhattacharya, T.K., Shukla, R., Chatterjee, R.N., Dushyanth, K. : |
| Knock down of the myostatin gene by RNA interference increased body weight in chicken. J Biotechnol :, 2016. Pubmed reference: 27845166 . DOI: 10.1016/j.jbiotec.2016.11.012. | |
| 2002 | Mott, I., Ivarie, R. : |
| Expression of myostatin is not altered in lines of poultry exhibiting myofiber hyper- and hypoplasia. Poult Sci 81:799-804, 2002. Pubmed reference: 12079046 . |
Edit History
- Created by Frank Nicholas on 18 Nov 2016
- Changed by Imke Tammen2 on 30 Aug 2021
- Changed by Imke Tammen2 on 19 Oct 2021