OMIA:000683-9925 : Muscular hypertrophy (double muscling) in Capra hircus |
In other species: cattle , pig , dog , chicken , rabbit , Japanese quail , sheep
Categories: Muscle phene
Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 601788 (gene) , 614160 (trait)
Links to MONDO diseases:
Mendelian trait/disorder: yes
Considered a defect: no
Key variant known: no
Cross-species summary: Abnormal increase in muscular tissue caused entirely by enlargement of existing cells (in contrast to muscular hyperplasia, in which the abnormal increase in muscular tissue is due to the formation and growth of new, normal muscle cells)
Species-specific description: This phene includes references to studies involving genetically modified organisms (GMO).
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| MSTN | myostatin | Capra hircus | 2 | NC_030809.1 (130232923..130227819) | MSTN | Homologene, Ensembl , NCBI gene |
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2023 | Kalds, P., Zhou, S., Huang, S., Gao, Y., Wang, X., Chen, Y. : |
| When less is more: Targeting the myostatin gene in livestock for augmenting meat production. J Agric Food Chem :, 2023. Pubmed reference: 36862946 . DOI: 10.1021/acs.jafc.2c08583. | |
| 2021 | Wang, X., Petersen, B. : |
| More abundant and healthier meat: will the MSTN editing epitome empower the commercialization of gene editing in livestock? Sci China Life Sci :, 2021. Pubmed reference: 34431041 . DOI: 10.1007/s11427-021-1980-4. | |
| 2018 | Wang, X., Niu, Y., Zhou, J., Zhu, H., Ma, B., Yu, H., Yan, H., Hua, J., Huang, X., Qu, L., Chen, Y. : |
| CRISPR/Cas9-mediated MSTN disruption and heritable mutagenesis in goats causes increased body mass. Anim Genet 49:43-51, 2018. Pubmed reference: 29446146 . DOI: 10.1111/age.12626. | |
| 2014 | Singh, S.P., Kumar, R., Kumari, P., Kumar, S., Mitra, A. : |
| Characterization of 5' upstream region and investigation of TTTTA deletion in 5' UTR of myostatin (MSTN) gene in Indian goat breeds. Anim Biotechnol 25:55-68, 2014. Pubmed reference: 24299184 . DOI: 10.1080/10495398.2013.821994. | |
| 2013 | Zhang, Z.J., Ling, Y.H., Wang, L.J., Hang, Y.F., Guo, X.F., Zhang, Y.H., Ding, J.P., Zhang, X.R. : |
| Polymorphisms of the myostatin gene (MSTN) and its relationship with growth traits in goat breeds. Genet Mol Res 12:965-71, 2013. Pubmed reference: 23613242 . DOI: 10.4238/2013.April.2.12. |
Edit History
- Created by Imke Tammen2 on 28 Aug 2021
- Changed by Imke Tammen2 on 28 Aug 2021