OMIA:001041-9615 : Ventricular septal defect in Canis lupus familiaris (dog)

In other species: chicken , turkey , domestic cat , horse , pig , taurine cattle , goat , sheep , rabbit , alpaca

Categories: Cardiovascular system phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 614429 (trait) , 614431 (trait) , 614432 (trait)

Mendelian trait/disorder: no

Mode of inheritance: Multifactorial

Considered a defect: yes

Key variant known: no

Cross-species summary: A congenital heart defect characterised by persistent patency (open-ness) of the ventricular septum, permitting flow of blood directly between ventricles, bypassing the pulmonary circulation and resulting in various degrees of cyanosis (blue discolouration of the skin) due to oxygen deficiency. Clinical signs include systolic murmur and a palpable thrill on both sides of the chest, dyspnoea and poor tolerance of exercise.

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2015). OMIA:001041-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2023 Aherne, M. :
Cardiac disease and screening in breeding dogs. Vet Clin North Am Small Anim Pract , 2023. Pubmed reference: 37353418. DOI: 10.1016/j.cvsm.2023.05.001.
Schrope, D. :
Acquired infundibular pulmonary stenosis associated with a congenital membranous ventricular septal defect (Gasul phenomenon) in a dog and discussion regarding causes of infundibular stenosis. J Vet Cardiol 47:64-69, 2023. Pubmed reference: 37247530. DOI: 10.1016/j.jvc.2023.05.001.
2020 Brambilla, P.G., Polli, M., Pradelli, D., Papa, M., Rizzi, R., Bagardi, M., Bussadori, C. :
Epidemiological study of congenital heart diseases in dogs: Prevalence, popularity, and volatility throughout twenty years of clinical practice. PLoS One 15:e0230160, 2020. Pubmed reference: 32716943. DOI: 10.1371/journal.pone.0230160.
2017 Belanger, J.M., Bellumori, T.P., Bannasch, D.L., Famula, T.R., Oberbauer, A.M. :
Correlation of neuter status and expression of heritable disorders. Canine Genet Epidemiol 4:6, 2017. Pubmed reference: 28560045. DOI: 10.1186/s40575-017-0044-6.
2015 Schrope, D.P. :
Prevalence of congenital heart disease in 76,301 mixed-breed dogs and 57,025 mixed-breed cats. J Vet Cardiol 17:192-202, 2015. Pubmed reference: 26363941. DOI: 10.1016/j.jvc.2015.06.001.
2013 Bellumori, T.P., Famula, T.R., Bannasch, D.L., Belanger, J.M., Oberbauer, A.M. :
Prevalence of inherited disorders among mixed-breed and purebred dogs: 27,254 cases (1995-2010). J Am Vet Med Assoc 242:1549-55, 2013. Pubmed reference: 23683021. DOI: 10.2460/javma.242.11.1549.
2011 Oliveira, P., Domenech, O., Silva, J., Vannini, S., Bussadori, R., Bussadori, C. :
Retrospective review of congenital heart disease in 976 dogs. J Vet Intern Med 25:477-83, 2011. Pubmed reference: 21418326. DOI: 10.1111/j.1939-1676.2011.0711.x.
2009 Diez-Prieto, I., García-Rodríguez, B., Ríos-Granja, A., Cano-Rábano, M., Peña-Penabad, M., García, C.P. :
Cardiac conotruncal malformations in a family of Beagle dogs. J Small Anim Pract 50:597-603, 2009. Pubmed reference: 19814768. DOI: 10.1111/j.1748-5827.2009.00815.x.
2005 Shimizu, M., Tanaka, R., Hirao, H., Kobayashi, M., Shimamura, S., Maruo, K., Yamane, Y. :
Percutaneous transcatheter coil embolization of a ventricular septal defect in a dog. J Am Vet Med Assoc 226:69-72, 52-3, 2005. Pubmed reference: 15646575.
2003 Baumgartner, C., Glaus, TM. :
[Congenital cardiac diseases in dogs: a retrospective analysis]. Schweiz Arch Tierheilkd 145:527-33, 535-6, 2003. Pubmed reference: 14639823.
Rausch, W.P., Keene, B.W. :
Spontaneous resolution of an isolated ventricular septal defect in a dog Journal of the American Veterinary Medical Association 223:219-20, 197, 2003. Pubmed reference: 12875450.
1999 Gehlen, H., Stadler, P., Deegen, E. :
Colour doppler technique and heart catheterization for haemodynamic evaluation of a ventricular septal defect - Case report Pferdeheilkunde 15:313-+, 1999.
Gehlen, H., Stadler, P., Deegen, E. :
Colour doppler technique and heart catheterization for haemodynamic evaluation of a ventricular septal defect - Case report Pferdeheilkunde 15:233-+, 1999.
1998 Vollmar, A., Huttig, A. :
Ventricular septal defect associated with aortic regurgitation in six dogs [German] Kleintierpraxis 43:911-+, 1998.
1995 Hunt, G.B., Pearson, M.R.B., Bellenger, C.R., Malik, R. :
Ventricular septal defect repair in a small dog using cross-circulation Australian Veterinary Journal 72:379-382, 1995. Pubmed reference: 8599570.
Skarda, R.T., Bednarski, R.M., Muir, W.W., Hubbell, J.A.E., Mason, D.E. :
Sedation and anesthesia in dogs and cats with cardiovascular disease Schweizer Archiv Fur Tierheilkunde 137:312-321, 1995. Pubmed reference: 7569846.
1993 Hagen, A., Keene, B. :
Presentation of a Ventricular Septum Defect in a Dog by Color- Doppler-Echocardiography, by Angiography and by Selective Oxymetry Schweizer Archiv Fur Tierheilkunde 135:268-271, 1993. Pubmed reference: 8211054.
1985 Matsuoka, S., Miyauchi, Y., Nakatsu, T., Yuasa, Y., Ueda, H., Miyao, M. :
Effect of respiratory acidosis on ventricular shunt flow and hemodynamics in dogs with ventricular septal defect. Jpn Circ J 49:499-506, 1985. Pubmed reference: 3927033.
1977 Eyster, G.E., Whipple, R.D., Anderson, L.K., Evans, A.T., O'Handley, P. :
Pulmonary artery banding for ventricular septal defect in dogs and cats. J Am Vet Med Assoc 170:434-8, 1977. Pubmed reference: 557030.
1974 Patterson, D.F., Pyle, R.L., Mierop, L. van, Melbin, J., Olson, M. :
Hereditary defects of the conotruncal septum in Keeshond dogs: pathologic and genetic studies American Journal of Cardiology 34:187-205, 1974. Pubmed reference: 4843154.
1973 Mulvihill, J.J., Priester, W.A. :
Congenital heart disease in dogs: epidemiologic similarities to man. Teratology 7:73-7, 1973. Pubmed reference: 4693746. DOI: 10.1002/tera.1420070111.
1972 [No authors listed] :
Correction of a ventricular septal defect in a dog. J Am Vet Med Assoc 161:507-12, 1972. Pubmed reference: 5052217.

Edit History

  • Created by Frank Nicholas on 06 Sep 2005
  • Changed by Frank Nicholas on 12 Dec 2015