OMIA:001041-9823 : Ventricular septal defect in Sus scrofa (pig)
Categories: Cardiovascular system phene
Links to MONDO diseases: No links.
Mendelian trait/disorder: unknown
Considered a defect: yes
Cross-species summary: A congenital heart defect characterised by persistent patency (open-ness) of the ventricular septum, permitting flow of blood directly between ventricles, bypassing the pulmonary circulation and resulting in various degrees of cyanosis (blue discolouration of the skin) due to oxygen deficiency. Clinical signs include systolic murmur and a palpable thrill on both sides of the chest, dyspnoea and poor tolerance of exercise.
Have human generated variants been created, e.g. through genetic engineering and gene editing
Cite this entry
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
|1996||Motsch, J., Weimann, J., Ehehalt, R., Bottiger, B.W., Jakob, H., Schnabel, P.A., Gebhard, M.M., Martin, E. :|
|Different effect of inhaled nitric oxide on yucatan micropig with and without congenital ventricular septal defect Journal of Experimental Animal Science 38:28-44, 1996. Pubmed reference: 8870413.|
|1993||Johnson, T.B., Fyfe, D.A., Thompson, R.P., Kline, C.H., Swindle, M.M., Anderson, R.H. :|
|Echocardiographic and Anatomic Correlation of Ventricular Septal Defect Morphology in Newborn Yucatan Pigs American Heart Journal 125:1067-1072, 1993. Pubmed reference: 8465729.|
|1991||Ho, S.Y., Thompson, R.P., Gibbs, S.R., Swindle, M.M., Anderson, R.H. :|
|Ventricular Septal Defects in a Family of Yucatan Miniature Pigs International Journal of Cardiology 33:419-426, 1991. Pubmed reference: 1761337.|
|1990||Swindle, M.M., Thompson, R.P., Carabello, B.A., Smith, A.C., Hepburn, B.J.S., Bodison, D.R., Corin, W., Fazel, A., Biederman, W.W.R., Spinale, F.G., Gillette, P.C. :|
|Heritable Ventricular Septal Defect in Yucatan Miniature Swine Laboratory Animal Science 40:155-161, 1990. Pubmed reference: 2157094.|
- Created by Frank Nicholas on 06 Sep 2005